Ghafuri DL, Abdullahi SU, Dambatta AH, Galadanci J, Tabari MA, Bello-Manga H, Idris N, Inuwa H, Tijjani A, Suleiman AA, Jibir BW, Gambo S, Gambo AI, Khalifa Y, Haliru L, Abdulrasheed S, Zakari MA, Greene BC, Trevathan E, Jordan LC, Aliyu MH, Baumann AA, DeBaun MR. Establishing Sickle Cell Disease Stroke Prevention Teams in Africa is Feasible: Program Evaluation Using the RE-AIM Framework. Journal of pediatric hematology/oncology. 2021 May 18. PMID: 34001783 [PubMed]
We used the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework to evaluate a Stroke Prevention Team's readiness to prevent strokes in children with sickle cell anemia living in northern Nigeria. The NIH sponsored Stroke Prevention Trial in Nigeria included a goal of a sustainable stroke prevention program. The program's 1-year reach for transcranial Doppler screening was 14.7% (4710/32,000) of which 6.0% (281/4710) had abnormal velocities (≥200 cm/s). All participants with abnormal transcranial Doppler velocities were started on hydroxyurea (effectiveness). The leaders of all 5 hospitals agreed to adopt the program. After 1 year, program-implementation and maintenance rates were 100%, demonstrating the program's feasibility and short-term sustainability.