Gras L, May M, Ryder LP, Trickey A, Helleberg M, Obel N, Thiebaut R, Guest J, Gill J, Crane H, Dias Lima V, DʼArminio Monforte A, Sterling TR, Miro J, Moreno S, Stephan C, Smith S, Tate J, Shepherd L, Saag M, Rieger A, Gillor D, Cavassini M, Montero M, Ingle SM, Reiss P, Constagliola D, Wit RWNM, Sterne J, De Wolf F, Geskus R. Determinants of Restoration of CD4 and CD8 Cell Counts and Their Ratio in HIV-1-Positive Individuals With Sustained Virological Suppression on Antiretroviral Therapy. Journal of acquired immune deficiency syndromes (1999). 2019 Mar 1;80(80). 292-300. PMID: 30531492 [PubMed] PMCID: PMC6392208
An increasing number of HIV-positive individuals now start antiretroviral therapy (ART) with high CD4 cell counts. We investigated whether this makes restoration of CD4 and CD8 cell counts and the CD4:CD8 ratio during virologically suppressive ART to median levels seen in HIV-uninfected individuals more likely and whether restoration depends on gender, age, and other individual characteristics.