The Vanderbilt University Medical Center (VUMC) Office of Federal Relations is located in Washington, D.C., and serves as the medical center's principle connection to federal policymakers on advocacy topics impacting VUMC patients, clinicians and researchers.

Managing more than 3 million outpatient visits each year and with over 1600 licensed inpatient beds, VUMC is one of the largest academic health systems in the Southeast and a resource for specialty and primary care in hundreds of adult and pediatric specialties for patients throughout Tennessee and the Mid-South.

In addition to its clinical care activities, VUMC is a major research hub annually ranking among the top recipients of funding from the NIH and other federal research sponsors. The health system also serves as a locus of medical training in the region, offering roughly 100 residency and fellowship programs and maintaining a house staff of approximately 1,200 residents and fellows.

The Vanderbilt Health system includes the main VUMC campus in Nashville (Davidson Co.) including Vanderbilt University Hospital, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt Psychiatric Hospital, Vanderbilt-Ingram Cancer Center and other highly specialized clinics and centers. Vanderbilt Health also incorporates several regional hospitals: Vanderbilt Wilson County Hospital (Wilson Co.), Vanderbilt Bedford Hospital (Bedford Co.), and Vanderbilt Tullahoma - Harton Hospital (Coffee Co.). Through the Vanderbilt Health Affiliated Network, VUMC is working with over 60 hospitals and 5,000 clinicians across Tennessee and five neighboring states to share best practices and bring value-driven and cost-effective health care to the Mid-South.

As of 2016, VUMC is an independent, nonprofit entity distinct from Vanderbilt University.