The Washington Post Mentions Dr. Crowe in Marburg Article

December 14, 2018

“She has awesome antibodies,” said James Crowe, a Vanderbilt University immunologist who is among the researchers who isolated one particularly powerful antibody from Barnes. An experimental vaccine is now in development.  Read more at On a Bat’s Wing and a Prayer.

Therapeutic Promise of a Human Antibody Against West Nile Virus

December 10, 2018

Flaviviruses are single-stranded RNA-containing, enveloped viruses that are primarily transmitted by insects (Figure 1). They include important human pathogens such as dengue virus, Zika virus, yellow fever virus, Japanese encephalitis virus, and west Nile virus (WNV). The most effective means to control these viral illnesses is through the development of vaccines; however, this has only been achieved in the case of yellow fever.

Vanderbilt team uses cancer cells to fight West Nile virus.

November 21, 2018

Researchers at Vanderbilt University Medical Center say they have used cancerous cells to mass produce a human antibody that can be used to “neutralize” West Nile virus, a mosquito-transferred illness that kills about 100 people in the U.S. each year. Their findings, revealed this week in a research paper published in the scientific journal Nature Microbiology, could lead to the first effective treatment for West Nile, according to a news release.

Nasal gene spray inspired by llama antibodies could prevent all types of flu

November 5, 2018

Four llama antibodies and a harmless virus: This outlandish recipe could be the basis of a nasal spray designed to foil infection from all strains of influenza. The spray, containing a virus engineered to make a protein derived from the llama antibodies, has passed its first animal test, protecting mice from every known flu strain that infects humans, a research team reports.  

Llamas may hold the key to a long-lasting flu jab

November 5, 2018

Llamas may hold the key to a long-lasting flu vaccine, research suggests.  Laboratory tests showed a protein produced by the fluffy animals, as well as camels, fought off the virus in mice.  Rodents were even protected against 60 strains of flu, which cause fever, headache and fatigue in humans, for more than nine months.  Currently, flu jabs protect against a maximum of four strains - meaning people can still be struck down by strains that were not predicted to be active.  The Belgian study has even raised hopes of a flu nasal spray, after the mice were equally protected when the vaccine w

Norovirus: Vanderbilt study takes step toward norovirus vaccine, medicinal treatment

September 10, 2018

Norovirus earned its name as the "perfect pathogen"because it spreads faster and farther than most viruses, infecting 20 million people in the United States every year and killing 200,000 worldwide. Although the virus - the leading cause of gastrointestinal illness - survives typical disinfectants and is constantly changing, researchers at Vanderbilt University have taken a step toward developing a vaccine and toward improving diagnosis and treatment.

Crowe Lab Team finds potent antibodies against three Ebola viruses

August 1, 2018

Researchers at Vanderbilt University Medical Center and their colleagues are a step closer to developing a broadly effective antibody treatment against the three major Ebola viruses that cause lethal disease in humans. Reporting July 17 in the journal Immunity, they describe the isolation of two potent monoclonal antibodies from human survivors of Ebola virus disease that, in cell culture studies, efficiently neutralized the Zaire, Sudan and Bundibugyo ebolaviruses.