VUMC partners with Batavia to move promising Zika antibody therapy closer to the clinic

September 9, 2019

Researchers at Vanderbilt University Medical Center (VUMC) are partnering with the Dutch biopharmaceutical firm Batavia Biosciences and Nashville-based IDBiologics to bring to the clinic a highly potent Zika virus neutralizing antibody they isolated three years ago. The mosquito-borne Zika virus is believed to cause microcephaly, unusually small heads, and other congenital malformations in children born to infected women. Currently there is no way to prevent Zika virus infection or its aftermath.

Laura Powell receives scholarship for the Keystone conference

March 20, 2019

Laura Powell has been awarded a Keystone Symposia Future of Science Fund scholarship to attend the upcoming meeting on Positive-Strand RNA Viruses, Jun 9 - Jun 13, 2019, in INEC, Killarney Convention Centre in Killarney, Co. Kerry.  Congrats Laura!

Can synthetic biology help Vanderbilt University Medical Center researchers develop therapeutic antibodies in only 90 days?

March 11, 2019

It seems as though every year there is another story of a virus rampaging through Africa, Asia, or even the Americas. And each time another Ebola outbreak occurs or the flu virus mutates in surprising ways, the conversation about global pandemic preparedness is rekindled. Borders are closed. Flights and cruise ships are cancelled. Images of quarantine tents and healthcare workers in space-like suits fill the news outlets.

First RNA-Delivered Antibody Set to Enter Clinical Trials

February 21, 2019

A monoclonal antibody against the chikungunya virus developed by researchers at Vanderbilt University Medical Center is the first monoclonal antibody encoded by messenger RNA to enter a clinical trial. Moderna Inc., a biotechnology firm based in Cambridge, Massachusetts, that is focused on developing mRNA-based vaccines and therapeutics, announced the clinical trial earlier this month.

Researchers comprehensively sequence the human immune system

February 14, 2019

For the first time ever, researchers are comprehensively sequencing the human immune system, which is billions of times larger than the human genome. In a new study published in Nature from the Human Vaccines Project, scientists have sequenced a key part of this vast and mysterious system -- the genes encoding the circulating B cell receptor repertoire.

Researchers push forward frontiers of vaccine science

February 13, 2019

Using sophisticated gene sequencing and computing techniques, researchers at Vanderbilt University Medical Center and the San Diego Supercomputer Center have achieved a first-of-its-kind glimpse into how the body’s immune system gears up to fight off infection. Their findings, published Feb. 13 in the journal Nature, could aid development of “rational vaccine design,” as well as improve detection, treatment and prevention of autoimmune diseases, infectious diseases, and cancer

DARPA and VUMC use high-throughput synthetic genes to hasten antibody discovery

January 30, 2019

Recent outbreaks of deadly viruses like Ebola, Zika and Monkeypox have shocked the world with their impact. In nature, the viruses typically lie dormant in their animal hosts, accruing mutations that change their genetic make-up significantly. Once an event occurs that allows the viruses to jump to humans, our immune systems are not prepared. The viruses spread rapidly, causing significant, life threatening infection, reminding us just how vulnerable we are to these diseases.

VUMC scientists ‘sprint’ to find anti-Zika antibodies

January 24, 2019

Scientists at Vanderbilt University Medical Center and colleagues in Boston, Seattle and St. Louis are racing to develop — in a mere 90 days — a protective antibody-based treatment that can stop the spread of the Zika virus. This is the first of four “scientific sprints” sponsored by the Defense Advanced Research Projects Agency (DARPA), part of the U.S. Department of Defense, under a five-year cooperative agreement worth up to $28 million that was signed last year.

The Washington Post Mentions Dr. Crowe in Marburg Article

December 14, 2018

“She has awesome antibodies,” said James Crowe, a Vanderbilt University immunologist who is among the researchers who isolated one particularly powerful antibody from Barnes. An experimental vaccine is now in development.  Read more at On a Bat’s Wing and a Prayer.

Therapeutic Promise of a Human Antibody Against West Nile Virus

December 10, 2018

Flaviviruses are single-stranded RNA-containing, enveloped viruses that are primarily transmitted by insects (Figure 1). They include important human pathogens such as dengue virus, Zika virus, yellow fever virus, Japanese encephalitis virus, and west Nile virus (WNV). The most effective means to control these viral illnesses is through the development of vaccines; however, this has only been achieved in the case of yellow fever.