eMERGE or e3 – is a multi-institutional project that has paved the way in using clinical data derived from electronic records with genomic data for discovery.  In this round of funding, one activity is testing participants (~2500 at each of 11 sites) for variants in approximately 100 genes and returning the results to participants to assess the impact on participants and physicians.  We are currently interviewing and administering surveys to participants and physicians who receive results.  These results will then be considered in conjunction with empirical evidence of what changes are made in patient care.