Internal Resources for VUMC Providers & Staff
What is PREDICT?
PREDICT (Pharmacogenomic Resource for Enhanced Decisions in Care & Treatment) is Vanderbilt Health’s personalized medicine initiative that uses pharmacogenetic test results in combination with clinical decision support to help guide drug dosing or selection.
Read more about the programmatic features:
- Operational implementation of prospective genotyping for personalized medicine: the design of the Vanderbilt PREDICT project
- Impact of Updating Pharmacogenetic Results: Lessons Learned from the PREDICT Program
- A Tutorial for Pharmacogenomics Implementation Through End-to-End Clinical Decision Support Based on Ten Years of Experience from PREDICT
What is the PREDICT (PDX) test?
The PREDICT test, also known as Pharmacogenetic Panel, is a panel-based, in-house laboratory test performed by the VUMC Molecular Diagnostics Lab. This test empowers patients and providers with important pharmacogenetic information to help optimize therapy and help prevent adverse drug events for select medications.
Learn the specifics about the PREDICT test and how to order: Using PREDICT Pharmacogenetic Panel
Why would the PREDICT test be ordered?
Genes play a role in how patients respond to medications. Based on the patient’s medication and clinical history, a provider may order a test to learn more about how a patient’s genetics affect response to medications. Having this information may help predict the right medication and right dose for a patient.
What diagnosis (ICD-10) codes are commonly associated with this test?
Providers should select an appropriate diagnosis code to reflect the nature of the lab service provided.
What does the test include?
The panel test includes ten genes and the CPT code associated with the test is 81418. The following drugs have clinical actionability that is supported through clinical decision support that fire alerts within the electronic health record when appropriate.
View the CPIC (Clinical Pharmacogenetics Implementation Consortium) guidelines to learn more about the clinical recommendations regarding pharmacogenetic results
| Gene | Description |
| CYP2C19 | Antiplatelet (Clopidogrel); Tricylcic Antidepressants; SSRIs; Antiepileptic; Proton pump inhibitors; Antifungal (Voriconazole) |
| CYP2D6 | Tricylclic Antidepressants; SSRIs; Beta blockers, Opioids (Codeine, Tramadol); Antiemetic (Ondansetron); ADHD Therapy (Atomoxetine); Antineoplastic (Tamoxifen) |
| SLCO1B1 | Lipid-lowering (statins - atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin) |
| CYP2C9 | Anticoagulant (warfarin), Lipid-lowering (statins - fluvastatin) |
| VKORC1 | Anticoagulant (warfarin) |
| CYP4F2 | Anticoagulant (Warfarin) |
CYP3A5 | Immunosuppressant (tacrolimus) |
| TPMT | Immunosuppressant (thiopurines - azathioprine, mercaptopurine, thioguanine) |
NUDT15 | Immunosuppressant (thiopurines - azathioprine, mercaptopurine, thioguanine) |
| DPYD | Chemotherapeutic (fluoropyrimidines - capecitabine, fluorouracil) |
Where can patients get tested?
Once an order is placed and active, patients can get their blood or buccal (cheek swab) sample collected at any Vanderbilt associated laboratory.
See all Vanderbilt laboratory locations.
Where can patients find the test results and other information about the PREDICT test?
Patients may view their PREDICT test results in My Health at Vanderbilt patient portal under the “Genetic Profile” section. Providers and other members of the patient’s care team may view a patient’s results in the Electronic Health Record. Additionally, patients may contact their provider for test results or additional information.
Patients can also read more about the PREDICT test here.
Billing questions
Patients with billing related questions should contact the Vanderbilt University Medical Center Patient Billing office at (615) 936-6523 or toll free at (877) 503-6890.
More questions
If you have questions about the PREDICT program, email predict@vumc.org, or for general information about PREDICT visit mydruggenome.org.