Shipe ME, Deppen SA, Sullivan S, Kammer M, Starnes SL, Wilson DO, Massion PP, Grogan EL. Validation of Histoplasmosis Enzyme Immunoassay to Evaluate Suspicious Lung Nodules. The Annals of thoracic surgery. 2020 Jul 16. PMID: 32682756 [PubMed]
Granulomas caused by infectious lung diseases can present as indeterminate pulmonary nodules (IPN). This study aims to validate an enzyme immunoassay (EIA) for histoplasma immunoglobulins G and M (IgG, IgM) for diagnosing benign IPN in areas with endemic histoplasmosis.