Anisowicz A, Huang H, Braunschweiger KI, Liu Z, Giese H, Wang H, Mamaev S, Olejnik J, Massion PP, Del Mastro RG. A high-throughput and sensitive method to measure global DNA methylation: application in lung cancer. BMC cancer. 2008 Aug 3;8(8). 222 p. PMID: 18673580 [PubMed] PMCID: PMC2546425
Genome-wide changes in DNA methylation are an epigenetic phenomenon that can lead to the development of disease. The study of global DNA methylation utilizes technology that requires both expensive equipment and highly specialized skill sets.