Isbell JM, Deppen S, Putnam JB, Nesbitt JC, Lambright ES, Dawes A, Massion PP, Speroff T, Jones DR, Grogan EL. Existing general population models inaccurately predict lung cancer risk in patients referred for surgical evaluation. The Annals of thoracic surgery. 2011 Jan;91(91). 227-33; discussion 233. PMID: 21172518 [PubMed] PMCID: PMC3748597 NIHMSID: NIHMS499604.
Patients undergoing resections for suspicious pulmonary lesions have a 9% to 55% benign rate. Validated prediction models exist to estimate the probability of malignancy in a general population and current practice guidelines recommend their use. We evaluated these models in a surgical population to determine the accuracy of existing models to predict benign or malignant disease.