Comparison of Diagnostic Bronchoscopy Single-Arm Trials Using an Advanced Optimization Approach for Indirect Comparisons with Partial Individual Patient Data.

The diagnostic yield of lung biopsy modalities is often compared using data from single-arm studies. These comparisons are biased due to differences in study populations, institutional practices, and diagnostic yield definitions. While individual patient data may be useful to account for some of these co-variables, individual patient data may only be available for one study. What is the difference in the primary outcome between two single-arm studies that utilized different bronchoscopy technologies?