Smith JT, Balar A, Lakhani DA, Kluwe C, Zhao Z, Kopparapu P, Almodovar K, Muterspaugh A, Yan Y, York S, Horn L, Antic S, Bertucci C, Shaffer T, Hodsdon L, Garg K, Hosseini SA, Lim L, Osmundson E, Massion PP, Lovly CM, Iams W. Circulating Tumor DNA as a Biomarker of Radiographic Tumor Burden in SCLC. JTO clinical and research reports. 2021 Mar;2(2). 100110 p. PMID: 34589992 [PubMed] PMCID: PMC8474385
Blood-based next-generation sequencing assays of circulating tumor DNA (ctDNA) have the ability to detect tumor-associated mutations in patients with SCLC. We sought to characterize the relationship between ctDNA mean variant allele frequency (VAF) and radiographic total-body tumor volume (TV) in patients with SCLC.