Deppen SA, Massion PP, Blume J, Walker RC, Antic S, Chen H, Durkin MM, Wheat LJ, Grogan EL. Accuracy of a Novel Histoplasmosis Enzyme Immunoassay to Evaluate Suspicious Lung Nodules. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2019 Dec;28(28). 321-326. PMID: 30341097 [PubMed] PMCID: PMC6363824 NIHMSID: NIHMS1509530.
Granulomas caused by infectious lung diseases present as indeterminate pulmonary nodules (IPNs) on radiography. Newly available serum enzyme immunoassay (EIA) for histoplasmosis has not been studied for the evaluation of IPNs. We investigated serum biomarkers of histoplasmosis antibodies as an indication of benign disease in IPNs from a highly endemic region.