Selected Research Publications:

Kryshtal DO, Blackwell D, Egly C, Smith AN, Batiste SM, Johnston JN, Laver DR, Knollmann BC. RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT. Circ Res. 2021 Feb 5;128(3):321-331. doi: 10.1161/CIRCRESAHA.120.316819. Epub 2020 Dec 10. PMID: 33297863. Click to download

Chavali NV, Kryshtal DO, Parikh SS, Wang L, Glazer AM, Blackwell DJ, Kroncke BM, Shoemaker MB, Knollmann BC. Patient-independent human induced pluripotent stem cell model: A new tool for rapid determination of genetic variant pathogenicity in long QT syndrome. Heart Rhythm. 2019 Apr 18. pii: S1547-5271(19)30360-1. doi: 10.1016/j.hrthm.2019.04.031. PMID: 31004778. Click to download

Batiste SM, Blackwell DJ, Kim K, Kryshtal DO, Gomez-Hurtado N, Rebbeck RT, Cornea RL, Johnston JN, Knollmann BC. Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4810-4815. doi: 10.1073/pnas.1816685116. PMID: 30792355. Click to download

Wang L, Kim K, Parikh S, Cadar AG, Bersell KR, He H, Pinto JR, Kryshtal DO, Knollmann BC. Hypertrophic cardiomyopathy-linked mutation in troponin T causes myofibrillar disarray and pro-arrhythmic action potential changes in human iPSC cardiomyocytes. J Mol Cell Cardiol. 2018 Jan;114:320-327. doi: 10.1016/j.yjmcc.2017.12.002. Click to download

Wang L, Kryshtal D, Kim K, Parikh S, Cadar A, Bersell K, He H, Pinto J, Knollmann B. Myofilament Ca-buffering dependent action potential triangulation in human iPSC model of hypertrophic cardiomyopathy. J Am Coll Cardiol. 2017 Nov 14;70(20):2600-2602. doi: 10.1016/j.jacc.2017.09.033. Click to download

Parikh SS, Blackwell DJ, Gomez-Hurtado N, Frisk M, Wang L, Kim K, Dahl CP, Fiane AE, Tønnessen T, Kryshtal DO, Louch WE, Knollmann BC. Thyroid and Glucocorticoid Hormones Promote Functional T-tubule Development in Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes. Circ Res. 2017 Oct 2. pii: CIRCRESAHA.117.311920. doi: 10.1161/CIRCRESAHA.117.311920. Click to download

Kannankeril PJ, Moore JP, Cerrone M, Priori SG, Kertesz NJ, Ro PS, Batra AS, Kaufman ES, Fairbrother DL, Saarel EV, Etheridge SP, Kanter RJ, Carboni MP, Dzurik MV, Fountain D, Chen H, Ely EW, Roden DM, Knollmann BC. Efficacy of Flecainide in the Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia: A Randomized Clinical Trial. JAMA Cardiol. 2017 Jul 1;2(7):759-766. doi: 10.1001/jamacardio.2017.1320. Click to download

Gomez-Hurtado N, Boczek NJ, Kryshtal DO, Johnson CN, Sun J, Nitu FR, Cornea RL, Chazin WJ, Calvert ML, Tester DJ, Ackerman MJ, Knollmann BC. Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks. Circ Arrhythm Electrophysiol. 2016 Aug;9(8). pii: e004161. doi: 10.1161/CIRCEP.116.004161. Click to download

Kryshtal DO, Dawling S, Seger D, Knollmann BC. In Vitro Studies Indicate Intravenous Lipid Emulsion Acts as Lipid Sink in Verapamil Poisoning. J Med Toxicol. 2016 Jun;12(2):165-71. doi: 10.1007/s13181-015-0511-y. Click to download

Feaster TK, Cadar AG, Wang L, Williams CH, Chun YW, Hempel J, Bloodworth N, Merryman WD, Lim CC, Wu JC, Knollmann BC, Hong CC. Matrigel Mattress: A Method for the Generation of Single Contracting Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circ Res. 2015 Oct 1. pii: CIRCRESAHA.115.307580.[Epub ahead of print] PubMed PMID: 26429802. Click to download

Hwang HS, Kryshtal DO, Feaster TK, Sánchez-Freire V, Zhang J, Kamp TJ, Hong CC, Wu JC,Knollmann BC. Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories. J Mol Cell Cardiol. 2015 Aug;85:79-88. doi: 10.1016/j.yjmcc.2015.05.003. strin 2. J Mol Cell Cardiol. 2015 May;82:75-83. doi: 10.1016/j.yjmcc.2015.02.027. Click for download

Kryshtal DO, Gryshchenko O, Gomez-Hurtado N, Knollmann BC. Impaired calcium-calmodulin-dependent inactivation of Cav1.2 contributes to loss of sarcoplasmic reticulum calcium release refractoriness in mice lacking calsequestrin 2. J Mol Cell Cardiol. 2015 May;82:75-83. doi: 10.1016/j.yjmcc.2015.02.027. Click to download

Hwang HS, Nitu FR, Yang Y, Walweel K, Pereira L, Johnson CN, Faggioni M, Chazin WJ, Laver D, George AL Jr, Cornea RL, Bers DM, Knollmann BC. Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants. Circ Res. 2014 Mar 28;114(7):1114-24. Click for download

Faggioni M, Savio-Galimberti E, Venkataraman R, Hwang HS, Kannankeril PJ, Darbar D, Knollmann BC. Suppression of spontaneous ca elevations prevents atrial fibrillation in calsequestrin 2-null hearts. Circ Arrhythm Electrophysiol. 2014 Apr;7(2):313-20. Click for download
Venkataraman R, Baldo MP, Hwang HS, Veltri T, Pinto JR, Baudenbacher FJ, Knollmann BC. Myofilament calcium de-sensitization and contractile uncoupling prevent pause-triggered ventricular tachycardia in mouse hearts with chronic myocardial infarction. J Mol Cell Cardiol. 2013 Jul;60:8-15. Click for download
Huke S, Venkataraman R, Faggioni M, Bennuri S, Hwang HS, Baudenbacher F, Knollmann BC. Focal energy deprivation underlies arrhythmia susceptibility in mice with calcium-sensitized myofilaments. Circ Res. 2013 May 10;112(10):1334-44. Click for download
Faggioni M, Hwang HS, van der Werf C, Nederend I, Kannankeril PJ, Wilde AA, Knollmann BC. Accelerated sinus rhythm prevents catecholaminergic polymorphic ventricular tachycardia in mice and in patients. Circ Res. 2013 Feb 15;112(4):689-97.Click for download
Feng W, Hwang HS, Kryshtal DO, Yang T, Padilla IT, Tiwary AK, Puschner B, Pessah IN, Knollmann BC. Coordinated regulation of murine cardiomyocyte contractility by nanomolar (-)-epigallocatechin-3-gallate, the major green tea catechin. Mol Pharmacol. 2012 Nov;82(5):993-1000. Click for download
Schober T, Huke S, Venkataraman R, Gryshchenko O, Kryshtal D, Hwang HS, Baudenbacher FJ, Knollmann BC. Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia. Circ Res. 2012 Jul 6;111(2):170-9. Click for download
Galimberti ES, Knollmann BC. Efficacy and potency of class I antiarrhythmic drugs for suppression of Ca2+ waves in permeabilized myocytes lacking calsequestrin. J Mol Cell Cardiol. 2011 Nov;51(5):760-8. Click for download
van der Werf C, Kannankeril PJ, Sacher F, Krahn AD, Viskin S, Leenhardt A, Shimizu W, Sumitomo N, Fish FA, Bhuiyan ZA, Willems AR, van der Veen MJ, Watanabe H, Laborderie J, Haïssaguerre M, Knollmann BC, Wilde AA. Flecainide therapy reduces exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. J Am Coll Cardiol. 2011 May 31;57(22):2244-54. Click for download
Hwang HS, Hasdemir C, Laver D, Mehra D, Turhan K, Faggioni M, Yin H, Knollmann BC. Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia. Circ Arrhythm Electrophysiol. 2011 Apr;4(2):128-35. Click for download.
Hilliard FA, Steele DS, Laver D, Yang Z, Le Marchand SJ, Chopra N, Piston DW, Huke S, Knollmann BC. Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass. J Mol Cell Cardiol. 2010 Feb;48(2):293-301. Click for download
Watanabe H, Chopra N, Laver D, Hwang HS, Davies SS, Roach DE, Duff HJ, Roden DM, Wilde AA, Knollmann BC. Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Nat Med. 2009 Apr;15(4):380-3. Click for download.
Baudenbacher F, Schober T, Pinto JR, Sidorov VY, Hilliard F, Solaro RJ, Potter JD, Knollmann BC. Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice. J Clin Invest. 2008 Dec;118(12):3893-903. Click for download.
Knollmann BC, Chopra N, Hlaing T, Akin B, Yang T, Ettensohn K, Knollmann BE, Horton KD, Weissman NJ, Holinstat I, Zhang W, Roden DM, Jones LR, Franzini-Armstrong C, Pfeifer K. Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia. J Clin Invest. 2006 Sep;116(9):2510-20. Click for download.


 Selected Reviews and Commentaries:

Wleklinski MJ, Kannankeril PJ, Knollmann BC. Molecular and tissue mechanisms of catecholaminergic polymorphic ventricular tachycardia. J Physiol. 2020 Jul;598(14):2817-2834. doi: 10.1113/JP276757. Epub 2020 Apr 27.PMID: 32115705. Click to download

Knollmann BC. Cardiac regulatory mechanisms: new concepts and challenges. J Physiol. 2017 Jun 15;595(12):3683-3684. doi: 10.1113/JP274290. Click to download

Gomez-Hurtado N, Blackwell DJ, Knollmann BC. Modelling human calmodulinopathies with induced pluripotent stem cells: progress and challenges. Cardiovasc Res. 2017 Apr 1;113(5):437-439. doi: 10.1093/cvr/cvx041. Click to download

Knollmann BC, Faggioni M. Arrhythmia Protection in Hypokalemia: A Novel Role of Ca2+-Activated K+ Currents in the Ventricle. Circulation. 2015 Sep 11. pii: CIRCULATIONAHA.115.018874. [Epub ahead of print] PubMed PMID: 26362635. Click to download

Eschenhagen T, Mummery C, Knollmann BC. Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes. Cardiovasc Res. 2015 Apr 1;105(4):424-38. doi: 10.1093/cvr/cvv017. Click for download

Gomez-Hurtado N, Knollmann BC. Calcium in atrial fibrillation - pulling the trigger or not? J Clin Invest. 2014 Nov;124(11):4684-6. doi: 10.1172/JCI77986. Click to download

Faggioni M, van der Werf C, Knollmann BC. Sinus node dysfunction in catecholaminergic polymorphic ventricular tachycardia: Risk factor and potential therapeutic target? (Review) Trends Cardiovasc Med. 2014 Jul 10. pii: S1050-1738(14)00057-7. Click to download
Roden DM, Knollmann BC. Dantrolene: from better bacon to a treatment for ventricular fibrillation. Circulation. 2014 Feb 25;129(8):834-6. Click for download
Roderick HL, Knollmann BC. Inositol 1,4,5-trisphosphate receptors: "exciting" players in cardiac excitation-contraction coupling? Circulation. 2013 Sep 17;128(12):1273-5. Click for download
Huke S, Knollmann BC. Familial hypertrophic cardiomyopathy: is the Frank-Starling law kaput? Circ Res. 2013 May 24;112(11):1409-11. Click for download
Knollmann BC. Induced pluripotent stem cell-derived cardiomyocytes: boutique science or valuable arrhythmia model? (Review) Circ Res. 2013 Mar 15;112(6):969-76. Click for download
Steele DS, Hwang HS, Knollmann BC. Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia. Cardiovasc Res. 2013 May 1;98(2):326-7. Click for download
Faggioni M, Kryshtal DO, Knollmann BC. Calsequestrin mutations and catecholaminergic polymorphic ventricular tachycardia. (Review)  Pediatr Cardiol. 2012 Aug;33(6):959-67. Click for download
Knollmann, B.C. Carvedilol tweaks calcium release to ease arrhythmias. Nat. Med. 2011 17:923-924. Click to download
Chopra N, Knollmann BC. Genetics of sudden cardiac death syndromes. (Review)  Curr Opin Cardiol. 2011 May;26(3):196-203. Click for download
A genetic framework for improving arrhythmia therapy. Knollmann BC, Roden DM. Nature. 2008 Feb 21;451(7181):929-36. Click to download

See our Full List of Publications.