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Alloimmunization
Apheresis
- What is the mechanism of action for Uvadex, the medication used in photopheresis
Methoxsalen (8-MOP) is a medication injected into the collection bag during the photopheresis procedure. This medication creates covalent bonds to pyrimidine bases in DNA, inhibiting the synthesis of DNA, and suppressing cell division. The augmented sunburn reaction involves excitation of the methoxsalen molecule by radiation in the long-wave ultraviolet light (UVA), resulting in transference of energy to the methoxsalen molecule producing an excited state. This medication is most frequently isolated from the fig plant.
- ECP Related questions, contact Lung Transplant Nurse Practitioner:
Laura Roberts: pager, 835-7864 OR Jean Barnes: pager, 835-9219 OR Jennifer Crichton, pager 865-8900
Blood Orders
Blood Donor
Blood Volume
- How do I calculate the total blood volume (TBV)
Fresh Frozen Plasma (FFP)
- How much Factor V exists in Fresh Frozen Plasma (FFP)?
Factor V levels in FFP can vary slightly with ABO group. On average the Factor V level in FFP is 100 IU/dL.
The half-life of Factor V is ~12 hours.
Miscellaneous
- ABO incompatibility table
- Aperhesis Procedure Consent
- Autoimmune hemolytic anemia guide
- Blood Administration Checklist
- Blood product transport while patient is in transport
- Differences between HDFN and NAIT
- Pathology residents -fellows 2013-2014
- RBC Exchange Resident Checklist
- What is the half-life of RHIG?
Platelet
- Platelet Refractoriness:
Corrected Count Increment Calculator
Body Surface Area Calculator - How many milliliters of intact red blood cells are there in an apheresis platelet product?
Per FDA standards a single apheresis platelet product must have less than 2 mL of RBC in an apheresis platelet product. If the product has more than 2 mL of RBCs then the product would require crossmatching. VUMC uses apheresis platelets that contain less than 2 mL of RBCs.
- Suspected Neonatal Alloimmune Thrombocytopenia:
BCW_NAIT form.pdf NAIT flow sheet BG_PP.pdf
- Suspected platelet refractoriness:
DCI platelet refractory order form
Product Modification
RBC
Shelf LIfe of Red Blood Cells based on different
anticoagulant/preservative solutions
- ACD/CPD/CP2D: 21 days
- CPDA-1: 35 days
- AS: 42 days
Transfusion Complication
Laboratory FAQs
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Bloody Truth
- Newsletters, "In the Know": Jan 2012; Feb 2012; Mar 2012; June 2012; Sept 2012; Oct 2012; Nov 2012; March 2013; October 2013; February 2014;
Miscellaneous-Lab
- ABO incompatibility table
- Can we transfuse Plasma-Lyte A along with a blood product?
The product is PLASMA-LYTE A (BAXTER) Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP). It is compatible with blood and blood components and can be administered prior to or following the infusion through the same tubing set, and it can also be infused through the same line during blood transfusion.
The minimum time needed for an antibody screen to be completed is 60 minutes. For complex immunohematologic evaluations, additional time may be required.
- How long does it take to perform an antibody screen?
- Lab Medicine Video
- LABORATORY LICENSES
- My patient has a positive antibody screen. Can I give O Negative blood if necessary?
If a patient has a positive antibody screen, it means they have developed an antibody to an antigen other than the ABO/Rh antigens. There are thousands of red cells antigens, and the only way to be certain the red blood cells (RBCs) will be compatible is to complete the antibody work up and crossmatch antigen negative blood.
- VUMC edocs – Search for LifeFlight
- VUMC Pathology Incoming Residents, 2014-2015
- What is the specificity of commonly used lectins?
- Red Blood Cell Lectin Specificity PDF
Effective IMMEDIATELY – Phlebotomist ID is required on all VUMC Blood Bank specimen labels. Samples received for VUMC Blood bank testing cannot be accepted unless Phlebotomist ID is on the specimen tube.
- Specimen Label Requirements
- Transfusion ABO/Rh reference guide “TRUTH TABLES”
- Vitamin K deficiency; Dr. Robert Sidonio, Vitamin K Deficiency
- VUMC Blood Bank Medical Technologist Question and Answer
- Weak ABO Subgroups
- Where do I find the LifeFlight Blood Product Log and LifeFlight Refrigerator Temperature forms?
Transfusion Complication
VUMC edocs (electronic documents)
- Where do I find the suspected transfusion reaction form?