Dr. Creech serves as Director of the VVRP, Prinicipal Investigator of the NIH-funded VTEU, and Co-Principal Investigator of the CDC-funded CISA Project. His research focuses primarily on the clinical and molecular epidemiology of S. aureus infections and on the immune response to vaccination and disease. He has served as PI for numerous vaccine studies in the VVRP including a Phase I malaria vaccine study, studies of live-attenauted influenza vaccine in children, and a randomized, placebo-controlled trial of clindamycin and trimethoprim-sulfamethoxazole in the treatment of skin and soft tissue infections. In 2007 he was the recipient of the IDSA/SHEA Young Investigator Award in MRSA and in 2012 he received the PIDS Young Investigator Award.
He currently is leading studies to determine the optimal duration of therapy for children with pneumonia; to define the immune response to influenza vaccination using a systems vaccinology approach; to define the immune response to S aureus infections in children and adults; and to compare whole-cell pertussis and acellular pertussis vaccines in children, using ribosome profiling as a transcriptomics tool.