The Crowe Lab uses a very broad array of techniques including molecular and cellular biology, state-of-the-art imaging and flow cytometry, bioinformatics, and bioengineering approaches to attack the scientific problems that are of interest to us. Our philosophy is to work on major human pathogens - we study model systems only when the direct study of the primary pathogen in humans is not feasible at a definitive level. Current studies center on respiratory syncytial virus, human metapneumovirus, rotavirus, HIV, influenza, and vaccinia virus.
At the interface of immunology and virology, recent computational advances have allowed us to better understand the interactions between antibodies and antigen, to design immunogens capable of eliciting target antibody specificities, and to optimize antibodies as clinical products. Research efforts in the Georgiev laboratory aim to utilize the power of computation to increase our understanding of fundamental questions in immunology and virology and to develop novel ways of using this understanding to fight diseases. For the translational component of our research, we apply structure-based protein design approaches to the development of new vaccine and antibody product candidates against a number of viruses of biomedical interest.