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2019 Symposium on Modeling Immunity

nathaa1 — Wed, 01 May 2019 17:00:00 +0000

2019 Symposium on Modeling Immunity nathaa1 Wed, 05/01/2019 - 12:00 RSS:

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Enabling Innovation Initiative Seminar: Jeff Conn and Brian Laden

nathaa1 — Fri, 05 Apr 2019 22:57:13 +0000

Enabling Innovation Initiative Seminar: Jeff Conn and Brian Laden nathaa1 Fri, 04/05/2019 - 17:57 RSS:

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Enabling Innovation Initiative Seminar: Kevin Ward

nathaa1 — Fri, 15 Mar 2019 20:00:00 +0000

Enabling Innovation Initiative Seminar: Kevin Ward nathaa1 Fri, 03/15/2019 - 15:00 RSS:

Join us Friday, March 15th at 3 PM in 202 Light Hall!

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VVC Seminar Series

Visitor — Thu, 29 Nov 2018 22:43:48 +0000

VVC Seminar Series Visitor Thu, 11/29/2018 - 16:43 RSS:

Join us Monday, December 3^rd from 11AM - Noon in 202 Light Hall!

"Structural and Functional Characterization of Broadly Reactive Antibodies Against Filoviruses Induced by Multivalent Immunization"

Gilad Adi Ofek, PhD

Department of Cell Biology and Molecular Genetics, Institute for Bioscience and Biotechnology Research
University of Maryland College Park, Rockville, MD 20850

During the 2014 outbreak of Ebola virus in West Africa, most immunotherapeutics and vaccines in late stage development were monospecific and lacked efficacy against other filoviruses that previously emerged. Efforts were thus initiated to isolate and characterize antibodies with broader efficacy. Such antibodies not only help expand the clinical toolkit against diverse future outbreaks, but also define sites of broad immune vulnerability for vaccine development. Several recent studies have shown that broadly-reactive neutralizing antibodies against ebolaviruses can be induced both in natural infection, as well as through animal immunizations. In this talk, I will discuss my lab’s efforts to structurally and functionally characterize broadly-reactive antibodies isolated from immunized nonhuman primates. Our approach has been based on immunization with multivalent cocktails of recombinant filovirus glycoproteins and virus like particles. Of particular recent focus has been a near pan-ebolavirus reactive antibody, CA45, that was induced by such immunizations. Our crystal structure of CA45 bound to the Ebola surface glycoprotein reveals that it targets a highly conserved site on the fusion loop stem of the glycoprotein, one that overlaps a previously defined pan-reactive inhibitor binding cavity. Through structural and functional analyses of antibodies elicited by immunization, we are defining novel molecular determinants on filoviruses that confer broad antibody recognition and neutralization – determinants that are being applied for further development of related therapeutics and vaccines.

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2017 Vanderbilt Symposium on Modeling Immunity

mcferrmd — Wed, 01 Mar 2017 23:25:09 +0000

2017 Vanderbilt Symposium on Modeling Immunity mcferrmd Wed, 03/01/2017 - 17:25 RSS:

Thursday, April 27

1:00 pm - 4:00 pm

1220 MRB III

Register by April 7 to guarantee lunch!
Reception to follow in MRB III lobby.

Speakers:

Sarel Fleishman, Ph.D.

Senior Scientist, Department of Biomolecular Sciences; Martha S. Sagon Career Development Chair, Weizmann Institute of Science

Frank DiMaio, Ph.D.

Assistant Professor, Department of Biochemistry, University of Washington

Steven Kleinstein, Ph.D.

Associate Professor of Pathology, Yale School of Medicine

Andrew Ward, Ph.D.

Associate Professor, Department of Integrative Structural and Computational Biology, The Scripps Research Institute

Jens Meiler, Ph.D.

Professor, Department of Chemistry and Pharmacology, Vanderbilt University

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2016 Vanderbilt Symposium on Modeling Immunity

mcferrmd — Thu, 04 Feb 2016 19:58:59 +0000

2016 Vanderbilt Symposium on Modeling Immunity mcferrmd Thu, 02/04/2016 - 13:58 RSS:

Thursday, April 28

9:00 am – 12:30 pm

202 Light Hall

Plenary Speaker:

David Baker, Ph.D.

Professor, Department of Biochemistry; Head of the Institute for Protein Design, University of Washington

Featured Speakers:

Ian Wilson, Ph.D.

Hansen Professor of Structural Biology; Chair, Department of Integrative Structural and Computational Biology, The Scripps Institute

Andrew Ward, Ph.D.

Associate Professor, Department of Integrative Structural and Computational Biology, The Scripps Institute

William Schief, Ph.D.

Professor, Department of Immunology and Microbial Science, The Scripps Institute

Jens Meiler, Ph.D.

Associate Professor, Department of Chemistry and Pharmacology, Vanderbilt University

James E. Crowe, Jr., M.D.

Professor, Department of Pediatrics and Pathology, Microbiology, and Immunology; Director, Vanderbilt Vaccine Center, Vanderbilt University

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Ebola Outbreak Symposium

Visitor — Tue, 16 Sep 2014 05:00:00 +0000

Ebola Outbreak Symposium

September 16, 2015

Visitor Tue, 09/16/2014 - 00:00 RSS:

Watch the full-length symposium here:

2015 Ebola Symposium

Vanderbilt Vaccine Center

Presents

“Ebola Outbreak in Nigeria 2014:
A First Hand Report from Survivors and Healthcare Providers”

Featuring

Benjamin Nnamdi Ohiaeri, M.D.

Founder and Chief Medical Director of First Consultants Medical Center Limited

Ada Igonoh, M.B.B.S.
Morris Ibeawuchi, M.B.B.S.
Ige Adewale Adejoro, M.B.B.S.

Ebola Survivors; Physicians, First Consultants Medical Center Limited

Hosted by

James E. Crowe Jr., MD
Ann Scott Carell Chair of Pediatrics and Pathology, Microbiology, and Immunology

2:00 – 3:30
Wednesday, September 16^th, 2015
208 Light Hall
Reception to Follow in Light Hall Lobby

The founder and Medical Director of First Consultants Medical Center in Lagos, Nigeria,
will be on campus to discuss how his hospital contained the Ebola outbreak in Lagos.
Three physicians from this hospital who survived Ebola are also traveling to Nashville to discuss their experience.

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Blog RSS

2019 Symposium on Modeling Immunity

Enabling Innovation Initiative Seminar: Jeff Conn and Brian Laden

Enabling Innovation Initiative Seminar: Kevin Ward

Join us Friday, March 15th at 3 PM in 202 Light Hall!

VVC Seminar Series

Join us Monday, December 3rd from 11AM - Noon in 202 Light Hall!

2017 Vanderbilt Symposium on Modeling Immunity

Thursday, April 27

1:00 pm - 4:00 pm

1220 MRB III

Register by April 7 to guarantee lunch! Reception to follow in MRB III lobby.

Speakers:​

Sarel Fleishman, Ph.D.

Senior Scientist, Department of Biomolecular Sciences; Martha S. Sagon Career Development Chair, Weizmann Institute of Science

Frank DiMaio, Ph.D.

Assistant Professor, Department of Biochemistry, University of Washington

Steven Kleinstein, Ph.D.

Associate Professor of Pathology, Yale School of Medicine

Andrew Ward, Ph.D.

Associate Professor, Department of Integrative Structural and Computational Biology, The Scripps Research Institute

Jens Meiler, Ph.D.

Professor, Department of Chemistry and Pharmacology, Vanderbilt University

2016 Vanderbilt Symposium on Modeling Immunity

Thursday, April 28

9:00 am – 12:30 pm

202 Light Hall

Plenary Speaker:

David Baker, Ph.D.

Professor, Department of Biochemistry; Head of the Institute for Protein Design, University of Washington

Featured Speakers:

Ian Wilson, Ph.D.

Hansen Professor of Structural Biology; Chair, Department of Integrative Structural and Computational Biology, The Scripps Institute

Andrew Ward, Ph.D.

Associate Professor, Department of Integrative Structural and Computational Biology, The Scripps Institute

William Schief, Ph.D.

Professor, Department of Immunology and Microbial Science, The Scripps Institute

Jens Meiler, Ph.D.

Associate Professor, Department of Chemistry and Pharmacology, Vanderbilt University

James E. Crowe, Jr., M.D.

Professor, Department of Pediatrics and Pathology, Microbiology, and Immunology; Director, Vanderbilt Vaccine Center, Vanderbilt University

Ebola Outbreak Symposium

Watch the full-length symposium here:

2015 Ebola Symposium

Vanderbilt Vaccine Center

Presents

“Ebola Outbreak in Nigeria 2014: A First Hand Report from Survivors and Healthcare Providers”

Benjamin Nnamdi Ohiaeri, M.D.

Ada Igonoh, M.B.B.S.Morris Ibeawuchi, M.B.B.S.Ige Adewale Adejoro, M.B.B.S.

Join us Monday, December 3^rd from 11AM - Noon in 202 Light Hall!

Register by April 7 to guarantee lunch!
Reception to follow in MRB III lobby.

Speakers:

“Ebola Outbreak in Nigeria 2014:
A First Hand Report from Survivors and Healthcare Providers”

Ada Igonoh, M.B.B.S.
Morris Ibeawuchi, M.B.B.S.
Ige Adewale Adejoro, M.B.B.S.