Silver HJ, Niswender KD, Keil CD, Jiang L, Feng Q, Chiu S, Krauss RM, Wilke RA. CNR1 genotype influences HDL-cholesterol response to change in dietary fat intake. PloS one. 7(7). e36166. PMID: 22567136 [PubMed] PMCID: PMC3342253
Success in further reducing the burden of cardiovascular disease (CVD) is threatened by the increasing prevalence of obesity-related atherogenic dyslipidemia. HDL-cholesterol (HDL-C) level is inversely correlated with CVD risk; each 1 mg/dl decrease in HDL-C is associated with a 6% reduction in risk. We previously showed that a common CNR1 haplotype, H3 (frequency 20%), is protective against the reduction in HDL-C that typically accompanies weight gain. In the present study, we extend that observation by reporting the effect of CNR1 haplotype on HDL-C response to modification of dietary fat intake in weight maintenance and weight loss.