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Siska PJ, Rathmell JC. Metabolic Signaling Drives IFN-γ. Cell metabolism. 2016 Nov 8;24(24). 651-652.
Abstract
IFN-γ is a critical inflammatory cytokine that is closely regulated to cellular metabolic status and requires high rates of glycolysis. It has now been shown that a key mechanism to link these pathways is through maintenance of acetyl-CoA and epigenetic regulation of the IFNG locus.