Gut Microbiome and p-Inulin in Hemodialysis
There are important potential benefits of intervening to restore symbiosis to the gut microbiota in patients with ESRD. However, before conducting clinical trials of such interventions, important gaps must be filled in the understanding of the composition, function and stability of the gut microbiota in patients with ESRD. The purpose of the Microbiome and PInulin in Hemodialysis Study is to fill some of these gaps in anticipation of ultimately investigating the therapeutic potential of altering the composition and/or function of the gut microbiome in this patient population. Intensive biosample collection from a small number of patients treated with hemodialysis before, during, and after treatment with p-inulin will be performed in order to generate information about within-participant and between-participant variability in the composition and metabolic products of the gut microbiome. The study will also provide information about the tolerability and safety of pinulin and the feasibility of biosample collection.