Publications

  • Ose J, Gigic B, Brezina S, Lin T, Peoples AR, Schobert PP, Baierl A, van Roekel E, Robinot N, Gicquiau A, Achaintre D, Scalbert A, van Duijnhoven FJB, Holowatyj AN, Gumpenberger T, Schrotz-King P, Ulrich AB, Ulvik A, Ueland PM, Weijenberg MP, Habermann N, Keski-Rahkonen P, Gsur A, Kok DE, Ulrich CM. Higher Plasma Creatinine Is Associated with an Increased Risk of Death in Patients with Non-Metastatic Rectal but Not Colon Cancer: Results from an International Cohort Consortium. Cancers (Basel). 2023 Jun 28;15(13):3391. doi: 10.3390/cancers15133391. PMID: 37444500; PMCID: PMC10340258.

  • Janczewski LM, Browner AE, Cotler JH, Nelson H, Kakar S, Carr NJ, Hanna NN, Holowatyj AN, Goldberg RM, Washington MK, Asare EA, Overman MJ; American Joint Committee on Cancer Expert Panel on Cancers for the Lower Gastrointestinal Appendix Disease Site. Survival outcomes used to validate version 9 of the American Joint Committee on Cancer staging system for appendiceal cancer. CA Cancer J Clin. 2023 Jun 26. doi: 10.3322/caac.21806. Epub ahead of print. PMID: 37358310.

  • Seagle HM, Keller SR, Tavtigian SV, Horton C, Holowatyj AN. Clinical Multigene Panel Testing Identifies Racial and Ethnic Differences in Germline Pathogenic Variants Among Patients With Early-Onset Colorectal Cancer. J Clin Oncol. 2023 Jun 15:JCO2202378. doi: 10.1200/JCO.22.02378. Epub ahead of print. PMID: 37319387.
  • Holowatyj AN, Washington MK, Horton C. Is Appendiceal Cancer a Lynch Syndrome-Associated Cancer?-Reply. JAMA Oncol. 2023 Apr 20. doi: 10.1001/jamaoncol.2023.0522. Epub ahead of print. PMID: 37079298.
  • Gigic B, van Roekel E, Holowatyj AN, Brezina S, Geijsen AJMR, Ulvik A, Ose J, Koole JL, Damerell V, Kiblawi R, Gumpenberger T, Lin T, Kvalheim G, Koelsch T, Kok DE, van Duijnhoven FJ, Bours MJ, Baierl A, Li CI, Grady W, Vickers K, Habermann N, Schneider M, Kampman E, Ueland PM, Ulrich A, Weijenberg M, Gsur A, Ulrich C; FOCUS Consortium. Cohort profile: Biomarkers related to folate-dependent one-carbon metabolism in colorectal cancer recurrence and survival - the FOCUS Consortium. BMJ Open. 2022 Dec 22;12(12):e062930. doi: 10.1136/bmjopen-2022-062930. PMID: 36549742; PMCID: PMC9772678.
  • Holowatyj AN, Wen W, Gibbs T, Seagle HM, Keller SR, Velez Edwards DR, Washington MK, Eng C, Perea J, Zheng W, Guo X. Racial/ethnic and sex differences in somatic cancer gene mutations among patients with early-onset colorectal cancer. Cancer Discov. 2022 Dec 15:CD-22-0764. doi: 10.1158/2159-8290.CD-22-0764. Epub ahead of print. PMID: 36520636. 
  • Himbert C, Stephens WZ, Gigic B, Hardikar S, Holowatyj AN, Lin T, Ose J, Swanson E, Ashworth A, Warby CA, Peoples AR, Nix D, Jedrzkiewicz J, Bronner M, Pickron B, Scaife C, Cohan JN, Schrotz-King P, Habermann N, Boehm J, Hullar M, Figueiredo JC, Toriola AT, Siegel EM, Li CI, Ulrich AB, Shibata D, Boucher K, Huang LC, Schneider M, Round JL, Ulrich CM. Differences in the gut microbiome by physical activity and BMI among colorectal cancer patients. Am J Cancer Res. 2022 Oct 15;12(10):4789-4801. PMID: 36381318; PMCID: PMC9641409. 
  • Holowatyj AN, Washington MK, Tavtigian SV, Eng C, Horton C. Inherited Cancer Susceptibility Gene Sequence Variations Among Patients With Appendix Cancer. JAMA Oncol. 2022 Nov 11. doi: 10.1001/jamaoncol.2022.5425. Epub ahead of print. PMID: 36368039
  • Daca-Alvarez M, Marti M, Spinelli A, de Miranda N, Palles C, Vivas A, Faiz O, Monahan K, Szczepkowski M, Tarnowski W, Makkai-Popa S, Tocino RV, Lopez I, Hurtado E, Jimenez F, Jimenez M, Alvaro E, Sanz G, Ballestero A, Melone S, Brandariz L, Prieto I, Ocaña T, Moreira R, Moreno L, Carballal S, Moreira L, Pellise M, Gonzalez-Sarmiento R, Holowatyj AN, Perea J, Balaguer F. Familial component of early-onset colorectal cancer: An opportunity for prevention. British Journal of Surgery. 2022. PMID: 36108087.
  • Pérez-Garcia J, Martel-Martel A, García-Vallés P, Corchete LA, García JL, Gestoso-Uzal N, Vidal-Tocino R, Blanco Ó, Méndez L, Sánchez-Martín M, Fuentes M, Herrero AB, Holowatyj AN, Perea J, González-Sarmiento R. Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration. Cancers (Basel). 2022 Aug 20;14(16):4029. doi:10.3390/cancers14164029. PMID: 36011023; PMCID: PMC9406593.
  • Richmond J, Sanderson M, Shrubsole MJ, Holowatyj AN, Schlundt D, Aldrich M. Psychosocial impact of COVID-19 among older adults in the southeastern United States. Prev Med. 2022 Aug 11;163:107191. doi: 10.1016/j.ypmed.2022.107191. Epub ahead of print. PMID: 35964774; PMCID: PMC9367170.
  • Holowatyj AN*, Ose J*, Gigic B, Lin T, Ulvik A, Geijsen AJMR, Brezina S, Kiblawi R, van Roekel EH, Baierl A, Bergmann MM, Boehm J, Bours MJL, Brenner H, Breukink SO, Chang-Claude J, de Wilt JHW, Grady WM, Grunberger T, Gumpenberger T, Herpel E, Hoffmeister M, Keulen ETP, Kok DE, Koole JL, Kosma K, Kouwenhoven EA, Kruyt FM, Kvalheim G, Li CI, Schirmacher P, Schrotz-King P, Singer MC, van Baar H, van Duijnhoven FJB, van Duijvendijk P, van Halteren HK, van Zutphen M, Vickers K, Vogelaar FJ, Warby CA, Wesselink E, Habermann N, Kampman E, Weijenberg MP, Ueland PM, Ulrich AB, Schneider MA, Gsur A, Ulrich CM. Higher vitamin B6 status is associated with improved survival among patients with stage I-III colorectal cancer. American Journal of Clinical Nutrition. 2022. Epub ahead of print. PMID: 35394006. *Contributed equally to this work.
  • Eng C, Holowatyj AN. Colorectal cancer genomics by genetic ancestry. Cancer Discovery. 2022. 12(5): 1187-1188. PMID: 35491647.
  • Choi J*, Holowatyj AN*, Du M, Chen Z, Wen W, Schultz ND, Lipworth L, Guo X. Distinct genomic landscapes in early-onset and late-onset endometrial cancer. JCO Precision Oncology. 2022. Epub ahead of print. PMID: 35108035. *Contributed equally to this work.
  • Perea J, Marti M, Espin E, Hernandez-Villafranca S, Orihuela P, Vidal R, Alcazar JA, Vivas A, Narvaez C, Prieto I, Asensio Gomez L, Lopez-Rojo I, Alonso S, Hurtado E, Jimenez LM, Jimenez F, Cavero A, Alvaro E, Jimenez-Tosacano M, Balaguer F, Daca M, Ballestero A, Die J, Sanz G, Melone S, Rueda JA, Brandariz L, Arredondo J, Pastor C, Garcia-Olmo D, Urioste M, Gonzalez-Sarmiento R, Spinelli A, Holowatyj AN. The Spanish Early-Onset Colorectal Cancer (SECOC) Cohort—a multi-center cohort study on the molecular basis of colorectal cancer among young individuals in Spain. BMJ Open. 2022. In press.
  • Eng C, Jacome AA, Agarwal R, Hayat MH, Byndloss MX, Holowatyj AN, Bailey CE, Lieu CH. A comprehensive framework for early-onset colorectal cancer research. The Lancet Oncology. 2022. 23(3): e116-e128. PMID: 35090673.
  • Holowatyj AN, Gigic B, Warby CA, Ose J, Lin T, Schrotz-King P, Ulrich CM, Bernard JJ. The use of human serum samples to study malignant transformation: A pilot study. Cells. 2021. 10(10): 2770. PMID: 34685650.
  • Holowatyj AN, Eng C, Lewis MA. Incorporating reproductive health in the clinical management of early-onset colorectal cancer. JCO Oncology Practice. 2021. 18(3): 169-172. PMID: 34554830.
  • Arhin N, Shen C, Bailey C, Matsuoka L, Hawkins A, Holowatyj AN, Ciombor K, Hopkins B, Geiger T, Kam A, Roth M, Lee C, Lapelusa M, Dasari A, Eng C. Surgical resection and survival outcomes in metastatic young adult colorectal cancer patients. Cancer Medicine. 2021. 10(13): 4269-4281. PMID: 34132476.
  • Holowatyj AN, Perea J, Lieu CH. Gut instinct: A call to study the biology of early-onset colorectal cancer disparities. Nature Reviews Cancer. 2021. 21(6): 339-340. PMID: 33833408.
  • Eisele Y, Mallea PM, Gigic B, Stephens WZ, Warby CA, Buhrke K, Lin T, Boehm J, Schrotz-King P, Hardikar S, Huang LC, Pickron TB, Scaife CL, Viskochil R, Koelsch T, Peoples AR, Pletneva MA, Bronner MP, Schneider M, Ulrich AB, Swanson EA, Toriola AT, Shibata D, Li CI, Siegel EM, Figueiredo JC, Janssen KP, Hauner H, Round J, Ulrich CM, Holowatyj AN*, Ose J*. Fusobacterium nucleatum and clinicopathologic features of colorectal cancer: Results from the ColoCare Study. Clinical Colorectal Cancer. 2021. 20(3): e165-e172. PMID: 33935016. *Contributed equally to this work.
  • Ose J, Gigic B, Brezina S, Lin T, Baierl A, Geijsen AJMR, Roekel E, Keski-Rahkonen P, Achaintre D, van Duijnhoven FJB, Gumpenberger T, Holowatyj AN, Kok DE, Koole A, Robinot N, Schrotz-King P, Ulrich AB, Schneider M, Ulvik A, Ueland PM, Kampman E, Weijenberg MP, Habermann N, Scalbert A, Gsur A, Ulrich CM. Targeted plasma metabolic profiles and risk of recurrence in stage II and III colorectal cancer patients: Results from an international cohort consortium. Metabolites. 2021. 11(3): 129. PMID: 33668370.
  • Gibbs T, Washington MK, Eng C, Idrees K, Davis J, Holowatyj AN. Histologic and racial/ethnic patterns of appendiceal cancer among young patients. Cancer Epidemiology, Biomarkers & Prevention. 2021. 30(6): 1149-1155. PMID: 33795212.
  • Koole JL, Bours MJL, Geijsen AJMR, Gigic B, Ulvik A, Kok DE, Baierl A, Bohm J, Brenner H, Breukink SO, Brezina S, Chang-Claude J, van Duijnhoven FJB, van Duijvendijk P, Gsur A, Gumpenberger T, Habermann N, van Halteren HK, Hoffmeister M, Holowatyj AN, Janssen-Heijnen ALG, Keulen ETP, Kiblawi R, Kruyt FM, Li CI, Lin T, Midttun O, Ose J, Peoples AR, van Roekel AH, Schneider M, Schrotz-King P, Ulrich AB, Vickers K, Wesselink E, de Wilt JHW, Ueland PM, Ulrich CM, Kampman E, Weijenberg MP. Circulating B-vitamin biomarkers and supplement use in relation to quality of life in patients with colorectal cancer: results from the FOCUS Consortium. American Journal of Clinical Nutrition. 2021. 113(6): 1468-1481. PMID: 33668069.
  • Tapial S, Garcia JL, Corchete L, Holowatyj AN, Perez J, Rueda D, Urioste M, Gonzalez-Sarmiento R, Perea J. Copy-neutral loss of heterozygosity (cnLOH) patterns in synchronous colorectal cancer. European Journal of Human Genetics. 2020. 29(4): 709-713. PMID: 33268847.
  • Holowatyj AN, Eng C, Wen W, Idrees K, Guo X. Spectrum of somatic cancer gene variations among adults with appendiceal cancer by age. JAMA Network Open. 2020. 3(12): e2028644. PMID: 33295976.
  • Holowatyj AN, Langston M, Han Y, Viskochil R, Perea J, Cao Y, Rogers CR, Lieu CH, Moore JX. Community health behaviors and geographic variation in early-onset colorectal cancer survival among women. Clinical and Translational Gastroenterology. 2020. 11(12): e00266. PMID: 33512797.
  • Holowatyj AN, Maude AS, Musa HS, Adamu A, Ibrahim S, Abdullahi A, Manko M, Aminu SM, Mohammed A, Idoko J, Ukwenya Y, Carpten J, Chandler PD, Hampel H, Faruk M. Patterns of early-onset colorectal cancer among Nigerians and African Americans. JCO Global Oncology. 2020. 6: 1647-1655. PMID: 33141623.
  • Ose D, Viskochil R, Holowatyj AN, Larson M, Wilson D, Dunson WA, Deshmukh V, Butcher JR, Taylor B, Svoboda K, Leiser J, Tingey B, Haaland B, Wetter D, Fischer S, Hashibe M, Ulrich CM. Understanding the prevalence of prediabetes and diabetes in cancer patients in clinical practice: A real-world cohort study. Journal of the National Comprehensive Cancer Network. 2021. 19(6): 709-718. PMID: 34129522.
  • Holowatyj AN*, Viskochil R*, Ose D, Tingey B, Haaland B, Wilson D, Larson M, Feltz S, Lewis MA, Colman H, Ulrich CM. Diabetes, body fatness, and insulin prescription among adolescents and young adults with cancer. Journal of Adolescent and Young Adult Oncology. 2021. 10(2): 217-225. PMID: 32749900. *Contributed equally to this work.
  • Geijsen AJMR, Ulvik A, Gigic B, Kok DE, van Duijnhoven FJ, Holowatyj AN, Brezina S, van Roekel EH, Baierl A, Bergmann MM, Boehm J, Bours MJ, Brenner H, Breukink SO, Chang-Claude J, de Wilt JH, Grady WM, Grunberger T, Gumpenberger T, Herpel E, Hoffmeister M, Keulen ET, Kiblawi R, Koole JL, Kosma K, Kouwenhoven EA, Kruyt FM, Kvalheim G, Li CI, Lin T, Ose J, Schirmacher P, Schneider MA, Schrotz-King P, Singer MC, van Duijvendijk P, van Halteren HK, van Zutphen M, Vickers K, Vogelaar FJ, Wesselink E, Habermann N, Ulrich AB, Ueland PM, Weijenberg MP, Gsur A, Ulrich CM, Kampman E. Circulating folate and folic acid concentrations: associations with colorectal cancer recurrence and survival. JNCI Cancer Spectrum. 2020. 4(5): pkaa051. PMID: 33134831.
  • Holowatyj AN, Haffa M, Lin T, Scherer D, Gigic B, Ose J, Warby CA, Himbert C, Abbenhardt-Martin C, Achaintre D, Boehm J, Boucher K, Gicquiau A, Gsur A, Habermann N, Herpel E, Kauczor HU, Keski-Rahkonen P, Kloor M, von Knebel-Doeberitz M, Kok DE, Nattenmueller J, Schirmacher P, Schneider M, Schrotz-King P, Simon T, Ueland PM, Viskochil R, Weijenberg MJ, Scalbert A, Ulrich AB, Bowers LW, Hursting SD, Ulrich CM. Multi-omics analysis reveals adipose-tumor crosstalk in colorectal cancer patients. Cancer Prevention Research. 2020. 13(10): 817-828. PMID: 32655010.
  • Holowatyj AN, Washington MK, Salaria SN, Lieu CH, Idrees K, Chandler PD, Hampel H, Martin RL, Lewis MA, Eng C. Early-onset appendiceal cancer survival by race or ethnicity in the United States. Gastroenterology. 2020. 159(4): 1605-1608. PMID: 32540351.
  • Rogers CR, Moore JX, Qeaden F, Gu LY, Huntington M, Holowatyj AN. Examining factors underlying geographic disparities in early-onset colorectal cancer survival among men in the United States. American Journal of Cancer Research. 2020. 10(5): 1592-1607. PMID: 32509399.
  • Hardikar S, Albrechtsen RD, Achaintre D, Lin T, Pauleck S, Playdon MC, Holowatyj AN, Gigic B, Schrotz-King P, Boehm J, Habermann N, Brezina S, Gsur A, van Roekel EH, Weijenberg MP, Keski-Rahkonen P, Scalbert A, Ose J, Ulrich CM. Impact of pre-blood collection factors on plasma metabolomic profiles. Metabolites. 2020. 10(5): 213. PMID: 32455751.
  • Ose J, Holowatyj AN, Nattenmueller J, Gigic B, Lin T, Himbert C, Habermann N, Achaintre D, Scalbert A, Keski-Rahkonen P, Boehm J, Schrotz-King P, Schneider M, Ulrich AB, Kampman E, Weijenberg M, Ueland PM, Gsur A, Kauczor HU, Ulrich CM. Metabolomics profiling of visceral and abdominal subcutaneous adipose tissue in colorectal cancer patients: Results from the ColoCare Study. Cancer Causes & Control. 2020. 31(8): 723-735. PMID: 32430684.
  • Kiblawi R, Holowatyj AN, Gigic B, Brezina S, Geijsen AJ, Ose J, Lin T, Hardikar S, Himbert C, Warby CA, Boehm J, Bours MJL, van Duijnhoven FJ, Gumpenberger T, Kok DE, Koole A, van Roekel EH, Schrotz-King P, Ulvik A, Gsur A, Habermann N, Kampman E, Weijenberg MP, Ueland PM, Schneider M, Ulrich AB, Ulrich CM, Playdon M. One-carbon metabolites, B-vitamins and associations with systemic inflammation and angiogenesis biomarkers among colorectal cancer patients: results from the ColoCare Study. British Journal of Nutrition. 2020. 123(10): 1187-1200. PMID: 32019627.
  • Archambault AN, Su YR, Jeon J, Thomas M, Lin Y, Conti DV, Win AK, Sadoka LC, Lansdorp-Vogelaar I, Peterse EFP, Zauber AG, Duggan D, Holowatyj AN, Huyghe JR, Brenner H, Cotterchio M, Bezieau S, Schmit SL, Edlund CK, Southey MC, MacInnis RJ, Campbell PT, Chang-Claude J, Slattery ML, Chan AT, Joshi AD, Song M, Cao Y, Woods MO, White E, Weinstein SJ, Ulrich CM, Hoffmeister M, Bien SA, Harrison TA, Hampe J, Li CI, Schafmayer C, Offit K, Pharoah PD, Moreno V, Lindblom A, Wolk A, Wu AH, Li L, Gunter MJ, Gsur A, Keku TO, Pearlman R, Bishop DT, Castellvi-Bel S, Moreira L, Vodicka P, Kampman E, Giles GG, Albanes D, Baron JA, Berndt SI, Brezina S, Buch S, Buchanan DD, Trichopoulou A, Severi G, Chirlaque MD, Sanchez SJ, Palli D, Kuhn T, Murphy N, Cross AJ, Burnett-Hartman AN, Chanock SJ, de la Chapelle A, Easton DF, Elliott F, English DR, Feskens EJM, FitzGerald LM, Goodman PJ, Hopper JL, Hudson TJ, Hunter DJ, Jacobs EJ, Joshu CE, Kury S, Markowitz SD, Milne RL, Platz EA, Rennert G, Rennert HS, Schumacher FR, Sandler RS, Seminara D, Tangen CM, Thibodeau SN, Toland AE, van Duijnhoven FJB, Visvanathan K, Vodickova L, Potter JD, Mannisto S, Weigl K, Figueiredo JC, Martin V, Larsson SC, Parfrey PS, Huang WY, Lenz HJ, Castelao JE, Gago-Dominguez M, Munoz-Garzon V, Mancao C, Haiman CA, Wilkens LR, Siegel E, Barry E, Younghusband B, Van Guelpen B, Harlid S, Zeleniuch-Jacquotte A, Liang PS, Du M, Casey G, Lindor NM, Le Marchand L, Gallinger SJ, Jenkins MA, Newcomb PA, Gruber SB, Schoen RE, Hampel H, Corley DA, Hsu L, Peters U, Hayes RB. Cumulative burden of colorectal cancer-associated genetic variants is more strongly associated with early-onset versus late-onset cancer. Gastroenterology. 2020. 158(5): 1274-1286.e12. PMID: 31866242.
  • Holowatyj AN, Gigic B, Herpel E, Scalbert A, Schneider M, Ulrich CM, Achaintre D, Brezina S, van Duijnhoven FJB, Gsur A, Keski-Rahkonen P, Weijenberg MP, Abbenhardt-Martin C, Boehm J, Boucher K, Habermann N, Haffa M, Hardikar S, Himbert C, Kauczor HU, Kloor M, Lampe PD, Lin T, Ose J, Scherer D, Schirmacher P, Schrotz-King P, von Knebel-Doeberitz M, Warby CA, Zhang Y, Ulrich AB, Swanson EA, Tavtigian SV. Distinct molecular phenotype of sporadic colorectal cancers among young patients based on multi-omics analysis. Gastroenterology. 2020. 158(4): 1155-1158.e2. PMID: 31730769.
  • Beyerle J*, Holowatyj AN*, Haffa M, Frei E, Gigic B, Schrotz-King P, Boehm J, Habermann N, Stiborova M, Scherer D, Kolsch T, Skender S, Becker N, Herpel E, Schneider M, Ulrich AB, Schirmacher P, Chang-Claude J, Brenner H, Hoffmeister M, Haug U, Owen RW, Ulrich CM. Expression patterns of xenobiotic-metabolizing enzymes in tumor and adjacent normal mucosa tissues among patients with colorectal cancer: The ColoCare Study. Cancer Epidemiology, Biomarkers & Prevention. 2020. 29(2): 460-469. PMID: 31740522. *Contributed equally to this work.
  • Holowatyj AN, Ulrich CM, Lewis MA. Racial/ethnic patterns of young-onset noncardia gastric cancer. Cancer Prevention Research. 2019. 12(11): 771-780. PMID: 31420363.
  • Geijsen AJ, van Roekel EH, van Duijhoven FJ, Achaintre D, Bachleitner-Hofmann T, Baierl A, Bergmann MM, Boehm J, Bours MJ, Brenner H, Breukink SO, Brezina S, Chang-Claude J, Herpel E, de Wilt JH, Gicquiau A, Gigic B, Gumpenberger T, Hansson BM, Hoffmeister M, Holowatyj AN, Karner-Hanusch J, Keski-Rahkonen P, Keulen ET, Koole JL, Leeb G, Ose J, Schirmacher P, Schneider MA, Schrotz-King P, Stift A, Ulvik A, Vogellar FJ, Wesselink E, van Zutphen M, Gsur A, Habermann N, Kampman E, Scalbert A, Ueland PM, Ulrich AB, Ulrich CM, Weijenberg MP, Kok DE. Plasma metabolites associated with colorectal cancer stage: findings from an international consortium. International Journal of Cancer. 2020. 146(12): 3256-3266. PMID: 31495913.
  • Holowatyj AN, Lewis MA, Pannier ST, Kirchhoff AC, Hardikar S, Figueiredo JC, Huang LC, Shibata D, Schmit SL, Ulrich CM. Clinicopathologic and racial/ethnic differences of colorectal cancer among adolescents and young adults. Clinical and Translational Gastroenterology. 2019. 10(7): e00059. PMID: 31259751.
  • Haffa M, Holowatyj AN, Kratz M, Toth R, Benner A, Gigic B, Habermann N, Schrotz-King P, Boehm J, Brenner H, Schneider M, Ulrich AB, Herpel E, Schirmacher P, Straub BK, Nattenmueller J, Kauczor HU, Lin T, Ball CR, Ulrich CM, Glimm H, Scherer D. Transcriptome profiling of adipose tissue reveals depot-specific metabolic alterations among colorectal cancer patients. The Journal of Clinical Endocrinology and Metabolism. 2019. 104(11): 5225-5237. PMID: 31225875.
  • Zhang P, Holowatyj AN, Ulrich CM, Edgar BA. Tumor suppressive autophagy in intestinal stem cells controls gut homeostasis. Autophagy. 2019. 15(9): 1668-1670. PMID: 31213134.
  • Zhang P, Holowatyj AN, Roy T, Marchetti M, Pronovost SM, Liu H, Ulrich CM, Edgar BA. An SH3PX1-dependent endocytosis-autophagy network restrains intestinal stem cell proliferation by counteracting EGFR-ERK signaling. Developmental Cell. 2019. 49(4): 574-589.e5. PMID: 31006650.
  • Holowatyj AN, Heath EI, Pappas LM, Ruterbusch JJ, Gorski DH, Triest JA, Park HK, Beebe-Dimmer JL, Schwartz AG, Cote ML, Schwartz KL. The epidemiology of cancer among homeless adults in metropolitan Detroit. JNCI Cancer Spectrum. 2019. 3(1): pkz006. PMID: 30944890.
  • Geijsen AJ, Brezina S, Keski-Rahkonen P, Baierl A, Bachleitner-Hofmann T, Bergmann MM, Boehm J, Brenner H, Chang-Claude J, van Duijnhoven FJ, Gigic B, Gumpenberger T, Hofer P, Hoffmeister M, Holowatyj AN, Karner-Hanusch J, Kok DE, Leeb G, Ulvik A, Robinot N, Ose J, Stift A, Schrotz-King P, Ulrich AB, Ueland PM, Kampman E, Scalbert A, Habermann N, Gsur A, Ulrich CM. Plasma metabolites associated with colorectal cancer: a discovery-replication strategy. International Journal of Cancer. 2019. 145(5): 1221-1231. PMID: 30665271.
  • Himbert C, Ose J, Nattenmueller J, Warby C, Holowatyj AN, Boehm J, Lin T, Haffa M, Gigic B, Hardikar S, Scherer D, Zielske L, Schrotz-King P, Koelsch T, Siegel E, Shibata D, Ulrich AB, Schneider M, Hursting SD, Kauczor HU, Ulrich CM. Body fatness, adipose tissue subtypes and biomarkers of inflammation and angiogenesis in colorectal cancer: the ColoCare Study. Cancer Epidemiology, Biomarkers & Prevention. 2019. 28(1): 76-82. PMID: 30333223.
  • Ulrich CM, Himbert C, Holowatyj AN, Hursting SD. Energy balance and gastrointestinal cancer: risk, interventions, outcomes, and mechanisms. Nature Reviews Gastroenterology and Hepatology. 2018. 15(11): 683-698. PMID: 30158569.
  • Bock CA, Ruterbusch JJ, Holowatyj AN, Steck S, Van Dyke AL, Ho WJ, Cote ML, Hofmann JN, Davis F, Graubard BI, Schwartz KL, Purdue MP. Renal cell carcinoma risk associated with lower intake of micronutrients. Cancer Medicine. 2018. 7(8): 4087-4097. PMID: 29968964.
  • Holowatyj AN, Cote ML, Ruterbusch JJ, Ghanem KM, Schwartz AG, Vigneau FD, Gorski DH, Purrington KS. Racial differences in 21-gene recurrence scores among patients with hormone receptor-positive, node-negative breast cancer. Journal of Clinical Oncology. 2018. 36(7): 652-658. PMID: 29341832.
  • Holowatyj AN, Ruterbusch JJ, Rozek LS, Cote ML, Stoffel EM. Racial/ethnic disparities in survival among patients with young-onset colorectal cancer. Journal of Clinical Oncology. 2016. 34(18): 2148-2156. PMID: 27138583.
  • Holowatyj AN, Ruterbusch JJ, Ratnam M, Gorski DH, Cote ML. HER2 status and disparities in luminal breast cancers. Cancer Medicine. 2016. 5(8): 2109-2116. PMID: 27250116.
  • Liu H, Liu L, Holowatyj A, Jiang Y, Yang ZQ. Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer. Molecular Carcinogenesis. 2016. 55(5): 977-990. PMID: 26207617.
  • Saeed MT, Ahmad J, Kanwal S, Holowatyj AN, Sheikh IA, Paracha RZ, Shafi A, Siddiqa A, Bibi Z, Khan M, Ali A. Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression. Peer J. 2016. 4: e2348. PMID: 27703839.
  • Ye Q*, Holowatyj A*, Wu J, Liu H, Zhang L, Suzuki T, Yang ZQ. Genetic alterations of KDM4 subfamily and therapeutic effect of novel demethylase inhibitor in breast cancer. American Journal of Cancer Research. 2015. 5(4): 1519-1530. PMID: 26101715. *Contributed equally to this work.
  • Liu L, Kimball S, Liu H, Holowatyj A, Yang ZQ. Genetic alterations of histone lysine methyltransferases and their significance in breast cancer. Oncotarget. 2015. 6(4): 2466-2482. PMID: 25537518.
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