The Center is continually engaged in new research applying decision analysis and cost-effectiveness modeling to specific domains of health care and health policy. The Center also conducts applications of mixed analytical methods, and is in continual development of new methods as part of its work. Below is a list of selected papers within these general research and care specialities.
Cardiovascular
Limdi NA, Cavallari LH, Lee CR, Hillegass WB, Holmes AM, Skaar TC, Pisu M, Dillon C, Beitelshees AL, Empey PE, Duarte JD et al. “Cost-effectiveness of CYP2C19-guided antiplatelet therapy in patients with acute coronary syndrome and percutaneous coronary intervention informed by real-world data.” The Pharmacogenomics Journal. 2020 Feb 11:1-2.
Zhu J, Kim KR, Yu H, Gupta A, Mushlin AI, Kamel H, Pandya A. Acute Ischemic Stroke Care Quality Improvement. JAMA Neurology. 2025.
Zhu J, Kamel H, Gupta A, Mushlin AI, Menzies NA, Gaziano TA, Rosenthal MB, Pandya A. Prioritizing Quality Measures in Acute Stroke Care: A Cost-Effectiveness Analysis. Annals of Internal Medicine. 2023.
Genetic Screening
Guzauskas GF, Jiang S, Garbett S, Zhou Z, Spencer SJ, Snyder SR, Graves JA, Williams MS, Hao J, Peterson JF, Veenstra DL. Cost-effectiveness of population-wide genomic screening for Lynch syndrome in the United States. Genetics in Medicine. 2022 Feb 25.
Guzauskas, Gregory F., Shawn Garbett, Zilu Zhou, Jonathan S. Schildcrout, John A. Graves, Marc S. Williams, Jing Hao et al. "Population genomic screening for three common hereditary conditions: a cost-effectiveness analysis." Annals of Internal Medicine 176, no. 5 (2023): 585-595.
Jiang S, Guzauskas GF, Garbett S, Graves JA, Williams MS, Hao J, Zhu J, Jarvik GP, Carlson JJ, Peterson JF, Veenstra DL. Cost-effectiveness of population-wide genomic screening for Lynch Syndrome and polygenic risk scores to inform colorectal cancer screening. Genetics in Medicine. 2025 Feb 1;27(2):101285.
Women's Health
Guzauskas GF, Garbett S, Zhou Z, Spencer SJ, Smith HS, Hao J, Hassen D, Snyder SR, Graves JA, Peterson JF, Williams MS. Cost-effectiveness of Population-Wide Genomic Screening for Hereditary Breast and Ovarian Cancer in the United States. JAMA Network Open. 2020 Oct 1;3(10):e2022874.
Leech AA, Garbett S, Yu HA, et al. Cost-Effectiveness of Treatment for Opioid Use Disorder in Pregnancy and Its Impact on Birth Outcomes. JAMA Pediatr. Published online September 08, 2025 doi:10.1001/jamapediatrics.2025.3067
Clifford CM, Askew N, Smith D, Iniguez J, Smith A, House MD, Leech AA. Prenatal aneuploidy screening in a low-risk Hispanic population: price elasticity and cost-effectiveness. AJOG Global Reports. 2024 February 1; 4(1): 100293.
Methods
Graves JA, Garbett S, Zhou Z, Schildcrout J, Peterson J. Comparison of Decision Modeling Approaches for Health Technology and Policy Evaluation. Medical Decision Making 41.4 (2021): 453-464.
Leech AA, Zhu J, Peterson H, Martin MH, Ratcliff G, Garbett S, Graves JA. Modeling Disability-Adjusted Life-Years for Policy and Decision Analysis. Medical Decision Making. 2025 May 28:0272989X251340077.
Sampson C, Zamora B, Watson S, Cairns J, Chalkidou K, Cubi-Molla P, Devlin N, García-Lorenzo B, Hughes DA, Leech AA, Towse A. Supply-Side Cost-Effectiveness Thresholds: Questions for Evidence-Based Policy. Applied Health Economics and Health Policy. 2022 Jun 7; 20(5): 651-667.
Network Analysis for Regulatory and Market Oversight
Crook H, Horta M, Michelson KA, Graves JA. Performance of health care service area definitions for capturing variation in inpatient care and social determinants of health. Health Services Research. 2024 May 2.
Michelson KA, Remick KE, Bucholz EM, McMullen PD, Singamsetty N, Skol AD, Cory DK, Graves JA. Network Analysis to Define Pediatric Acute Care Regions in Wisconsin. Health Serv Res. 2025 Jul 2. DOI: 10.1111/1475-6773.70000.
Michelson KA, Skol AD, Graves JA, Remick KE, McMullen PD, Singamsetty N, Cory DK, Bucholz EM, A Whole United States Atlas of Pediatric Acute Care, JAMA: Pediatrics, in press.