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Trujillo P, Roman OC, Hay KR, Juttukonda MR, Yan Y**, Kang H*, Paranjape SY, Garland EM, Shibao CA, Biaggioni I, Donahue MJ, Claassen DO. Elevated cerebral blood flow in patients with pure autonomic failure. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 2021 Jun;31(31). 405-414. NIHMSID: NIHMS1787114.
Abstract
Pure autonomic failure (PAF) results from an impaired peripheral autonomic nervous system, and clinical symptoms present with orthostatic hypotension. While the impact on cardiovascular indices of orthostatic intolerance are well-characterized, more limited information is available regarding cerebral hemodynamic dysfunction in PAF. The objective of this study was to test the hypothesis that cerebral blood flow (CBF) is reduced in PAF, and to quantify the relationship between CBF and clinical indicators of disease severity, including peripheral supine arterial blood pressure.