Title: Integrated Health Services to Reduce Opioid Use While Managing Chronic Pain

Funded by the Patient-Centered Outcomes Research Institute (PCORI), PI: McCormack, RTI International


Recently declared a public health emergency, opioids have claimed the lives of over half a million people between 2000 to 2015. Every day an average of 91 Americans die from an opioid overdose. One of the driving forces of this epidemic has been the use of prescription opioids for chronic pain. However the effectiveness of opioid therapy is unclear and exposes patients to potential risks, including addiction. Safer treatment options for long term management of chronic pain are needed.

This pragmatic trial is a collaboration between RTI International, Vanderbilt University Medical Center, University of North Carolina, and Duke University. Dr. Archer is the site PI for the Vanderbilt site. This trial will help patients better understand the risks, benefits, and uncertainties associated with opioid use and will receive other treatment options for managing their pain. Patients on chronic opioid therapy seen in primary care or pain clinics will be randomized to guideline-concordant pharmacotherapy with shared decision making (Arm 1) or guideline-concordant pharmacotherapy with motivational interviewing (MI) and cognitive behavioral therapy (Arm 2).