Spatiotemporal Dynamics of ICU Delirium in Hospitalized Nonagenarians
In this study, we are evaluating whether the EEG Delirium Index, which we previously developed using the pilot data from a cohort of mechanically ventilated participants in the ICU, can be generalized to a separate group of hospitalized patients with and without preexisting dementia. This study was conducted in a retrospective cohort of patients at Vanderbilt, after ethics approval by the Institutional Review Board.
Characterizing the Spectral EEG Patterns Differentiating Delirium Phenotypes
Delirium can be categorized into distinct clinical phenotypes based on the likely precipitating etiologies (causes). We previously identified an electroencephalography (EEG)-based signature of delirium, using spectral and complexity metrics of raw EEG recordings. In this retrospective observational study, we hypothesize that clinical delirium phenotypes are associated with characteristic spectral, complexity and functional connectivity patterns on scalp EEG.
Feasibility of Neuro Feedback Training in ICU Survivors: A Pilot Study
An estimated 27-40% of Intensive Care Unit (ICU) survivors suffer new or worsening anxiety, depression, impaired cognition and/or post-traumatic stress symptoms. These psychological manifestations of so-called Post-Intensive Care Syndrome (PICS) are associated with worse physical functioning, lower employment rates and worse mental health-related quality of life. Major depression, generalized anxiety disorder and post-traumatic stress disorder are all associated with changes in brain functional connectivity and oscillatory patterns measurable by electroencephalography (EEG).