Exploring Statin Pleiotropic Effects within a Very Large EHR Cohort
Statins among the most widely prescribed agents worldwide for prevention of cardiovascular diseases, produce substantial pleiotropic effects. Pleiotropic effects are unanticipated outcomes other than those for which the drug was originally developed, either therapeutic (beneficial) or detrimental (adverse drug reactions). Statin pleiotropic effects are unanticipatedly broad, including increasing the risk of developing type 2 diabetes mellitus and cataract, decreasing cancer-related mortality, and reducing dementia. Many effects are still not determined. We investigate statin pleiotropic effects using whole de-identified electronic health records (EHRs) of >2 million patients at Vanderbilt (including 10,000 genotyped statin recipients) to answer these questions.
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