Matthew S. Freiberg, MD, MSc

Founding Director V-CREATE; Professor of Medicine Cardiovascular Medicine; Dorothy and Laurence Grossman Chair in Cardiology
Division of Cardiovascular Medicine

My research focuses on the intersections between HIV infection, substance use, immune function, and cardiovascular disease outcomes.


I am an internal medicine physician and cardiovascular epidemiologist. I am a Professor of Medicine in the Division of Cardiovascular Medicine, Director of the Vanderbilt Center for Clinical Cardiovascular Outcomes REsearch and Trials Evaluation (V-CREATE), and the Dorothy and Laurence Grossman Chair in Cardiology. Originally from the Pacific Northwest, I received my BS from the University of Washington and completed medical school at Oregon Health Sciences University. I completed postgraduate training as a resident at University of Chicago Hospitals and fellowships at Boston University and the Framingham Heart Study. My research interests include the impact of HIV, inflammation, altered immunity, and alcohol use on cardiovascular outcomes. I specialize in utilizing big data for clinical research initiatives. I have been a Veterans Aging Cohort Study (VACS) investigator for nearly 10 years and am presently principal investigator on four NIH-funded VACS ancillary studies, including three R01 grants. My work also includes international initiatives with the Uganda, Russia, Boston Alcohol Network for Alcohol Research Collaboration on HIV/AIDS (URBAN ARCH) Consortium as an investigator with the Russia Cohort. I am the principal investigator of a study examining the impacts of HIV and heavy alcohol use on the microbiome, inflammation, coronary heart disease, and total mortality among ARCH participants in St. Petersburg, Russia.