Clinical Practice Guidelines: Hyperinflammation

CLINICAL PRACTICE GUIDELINES (FULL LIST)

Hyperinflammation (CPG)

A need was identified to create a multidisciplinary care by multiple pediatric subspecialty teams to assist in the identification, diagnosis, and treatment of systemic hyperinflammation including hemophagocytic lymphohistiocytosis (HLH) for patients admitted to Monroe Carell Jr. Children’s Hospital at Vanderbilt. HLH and other immune dysregulation are rare diagnoses that can be primary (congenital, genetic) or secondary (caused by another disease state which can be infectious, malignant, or rheumatologic in nature). It leads to hyperinflammation which can impact multiple organ systems and lead to critical illness. In current state, multiple subspecialty teams may be consulted on a patient, but there is not a standardized multidisciplinary recommendation. With implementation of the new consult team, these subspecialties will create a unified recommendation for any diagnostic testing or treatments based on interdisciplinary discussions. This team has already been assembled, and together, the team has created clinical practice guidelines based on publications by other large children’s hospitals (PMID: 40124385, 35840156, 30764840).

Authors:

  • Nephrology: Rene VanDeVoorde
  • Hepatology: Anita Pai
  • Rheumatology: Brent Graham, Anna Patrick, Tyler Reese
  • Allergy/Immunology: Yasmin Khan
  • Genetics: Thomas Cassini
  • Infectious Disease: Dan Dulek, Natalia Beneschott, Walter Dehority, Kim Okafor
  • ICU: Ryan Stark, Matthew Solomon
  • Hematology: Heather McDaniel
  • Hematopoietic Cell Transplant: Jim Connelly
  • Bioinformatics: Brandon Buxton, Allison McCoy
  • Quality Improvement: Christine Smith
  • Hospitalist: Brooke Quertermous
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