Clinical Practice Guidelines: Status Epilepticus



Generalized convulsive status epilepticus is the most common neurologic emergency in childhood, with an incidence of 17-23/100,000. It is defined as continuous seizure activity for more than five minutes or recurrent seizure activity without return to baseline mental status for more than five minutes. Status epilepticus requires immediate and targeted treatment to reduce the risk of mortality (2 to 5 percent) and morbidity. Refractory status epilepticus is defined as status epilepticus that is not responsive to standard treatment regimens (usually a seizure that lasts longer than 30 minutes) and carries an even higher risk of mortality (17 percent), thus making it important to identify and treat status epilepticus as quickly and as effectively as possible.  

With the help of a multidisciplinary team involving pediatric neurology, emergency medicine, pediatric critical care and pharmacy, this clinical practice guideline based on current evidence and best practices, was developed with the goal of effectively and efficiently treating patients with status epilepticus to help improve clinical outcomes.

Status epilepticus guidelines team

  • Contact: Shilpa Reddy, Pediatric Neurology
  • Michael Wolf (PICU)
  • Lindsay Pagano (neurology)
  • Emma Carter (neurology)
  • Jessica Anderson (pharmacy)
  • Meredith Diaz (pharmacy)
  • Richard Carozza (neurology)
  • Cary Fu, Pediatrics
  • Truc Le, Pediatric Critical Care
  • Daniel Barrett, Pediatric Critical Care
  • Jamie Otillo, Emergency Medicine
  • Julie Pingel, Pharmacy