Clinical Practice Guidelines: Musculoskeletal Infection



Musculoskeletal Infection CPG Supporting Evidence

Musculoskeletal infections (MSKI) are a common cause of pediatric hospitalization and prolonged antibiotic use.  This clinical practice guideline was developed with the goals of optimizing therapy by increasing the likelihood of organism identification and susceptibility testing, decreasing cost by avoiding unnecessary studies and hospital days and ensuring evidence-based care when relevant data exist.

MSKI guideline team

  • Contacts:  Sophie Katz, Infectious Diseases and Jeffrey Martus, Orthopedic Surgery
  • Steven Barron Frazier, Emergency Medicine
  • Michelle Walsh, Emergency Medicine
  • Alison Carroll, Hospital Medicine
  • My-Linh Ngo, Hospital Medicine
  • Ritu Banerjee, Infectious Diseases


  1. Zhorne, D. J., et al. (2015). "Impact of antibiotic pretreatment on bone biopsy yield for children with acute hematogenous ostemyelitis." Hosp Pediatr 5(6): 337-341.
  2. van der Merwe, M., et al. (2019). "The effect of antibiotic timing on culture yield in paediatric osteoarticular infection." J Child Orthop 13(3): 114-119.
  3. Benvenuti, M. A., et al. (2019). "Effects of Antibiotic Timing on Culture Results and Clinical Outcomes in Pediatric Musculoskeletal Infection." J Pediar Orthop 39(3): 158-162.
  4. Amaro, E., et al. (2019). "C-Reactive Protein Predicts Risk of Venous Thromboembolism in Pediatric Musculoskeletal Infection." H Pediatr Orthop 39(1): e62-e67.