Smooth muscle mineralocorticoid receptor as an epigenetic regulator of vascular aging.

Abstract

Vascular stiffness increases with age and independently predicts cardiovascular disease risk. Epigenetic changes, including histone modifications, accumulate with age but the global pattern has not been elucidated nor are the regulators known. Smooth muscle cell-mineralocorticoid receptor (SMC-MR) contributes to vascular stiffness in aging mice. Thus, we investigated the regulatory role of SMC-MR in vascular epigenetics and stiffness.