Talati MH, Brittain EL, Fessel JP, Penner N, Atkinson J, Funke M, Grueter C, Jerome WG, Freeman M, Newman JH, West J, Hemnes AR. Mechanisms of Lipid Accumulation in the Bone Morphogenic Protein Receptor 2 Mutant Right Ventricle. American journal of respiratory and critical care medicine. 2016 Apr 14. PMID: 27077479 [PubMed]
In heritable pulmonary arterial hypertension (HPAH) with germline mutation in the bone morphogenetic protein receptor 2 (BMPR2) gene, right ventricular (RV) dysfunction is associated with RV lipotoxicity, however the underlying mechanism for lipid accumulation is not known.