Bachmann KN, Huang S, Lee H, Dichtel LE, Gupta DK, Burnett JC, Miller KK, Wang TJ, Finkelstein JS. Effect of Testosterone on Natriuretic Peptide Levels. Journal of the American College of Cardiology. 2019 Mar 26;73(73). 1288-1296. PMID: 30898204 [PubMed] PMCID: PMC6588352 NIHMSID: NIHMS1522183.
Circulating natriuretic peptide (NP) levels are markedly lower in healthy men than women. A relative NP deficiency in men could contribute to their higher risk of hypertension and cardiovascular disease. Epidemiological studies suggest testosterone may contribute to sex-specific NP differences.