Januzzi JL, Lyass A, Liu Y, Gaggin H, Trebnick A, Maisel AS, D'Agostino RB, Wang TJ, Massaro J, Vasan RS. Circulating Proneurotensin Concentrations and Cardiovascular Disease Events in the Community: The Framingham Heart Study. Arteriosclerosis, thrombosis, and vascular biology. 2016 Aug;36(36). 1692-7. PMID: 27312221 [PubMed] PMCID: PMC4965295 NIHMSID: NIHMS793656.
Neurotensin is a peptide whose receptor (sortilin receptor 1) is linked to cardiovascular disease (CVD) development. We hypothesized concentrations of proneurotensin (stable profragment of neurotensin) would predict incident cardiovascular events in community-based subjects.