Kuipers AL, Miljkovic I, Carr JJ, Terry JG, Nestlerode CS, Ge Y, Bunker CH, Patrick AL, Zmuda JM. Association of circulating sclerostin with vascular calcification in Afro-Caribbean men. Atherosclerosis. 2015 Mar;239(239). 218-23. PMID: 25618029 [PubMed] PMCID: PMC4331206 NIHMSID: NIHMS658106.
Sclerostin, a Wingless (Wnt) pathway antagonist, is an established regulator of bone mineralization in humans but its potential importance in the regulation of vascular calcification is less clear. Therefore, our objective was to assess the relationship of serum sclerostin levels with coronary and aortic artery calcification (CAC and AAC, respectively) in Afro-Caribbean men on the island of Tobago.