Ardina (Andrea) J. Pruijssers, Ph.D.

Research Assistant Professor of Pediatrics

D-6209 Medical Center North
1161 21st Avenue South
Nashville
Tennessee
37232-2582
Phone
615-343-8977

Coronavirus antiviral therapies

Andrea earned a Masters of Science in Cell and Molecular Biology from Wageningen University in Wageningen, The Netherlands, and a PhD in Entomology from the University of Georgia in Athens, Georgia. She received postdoctoral training in the laboratory of Terence Dermody at Vanderbilt University Medical Center.

Research Description

My research focuses on the development of antiviral therapies for emerging coronavirus (CoV) infections. Most CoV infections cause upper respiratory infections such as the common cold. However, CoVs can cause more severe disease with high mortality rates when they jump from animals into humans. The severe acute respiratory syndrome (SARS)-CoV outbreak in 2002 and the ongoing Middle East respiratory syndrome (MERS)-CoVs are examples of this. No licensed drugs or vaccines are currently available to prevent or treat CoV infections. We are currently testing combinations of direct-acting antivirals for their efficacy and potency against CoV infection. We also study the mechanisms by which CoVs develop resistance against drugs so that we can design therapeutic regimens that prevent this. 

Publications on PubMed.gov