Sharp TM, Muñoz-Jordán J, Perez-Padilla J, Bello-Pagán MI, Rivera A, Pastula DM, Salinas JL, Martínez Mendez JH, Méndez M, Powers AM, Waterman S, Rivera-García B. Zika Virus Infection Associated With Severe Thrombocytopenia. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2016 Nov 1;63(63). 1198-1201. PMID: 27418575 [PubMed] PMCID: PMC5176332 NIHMSID: NIHMS836216.
We report two patients that developed severe thrombocytopenia after Zika virus (ZIKV) infection. The first patient had 1000 platelets/μL and died after multiple hemorrhages. The second patient had 2000 platelets/μL, had melena and ecchymoses, and recovered after receiving intravenous immunoglobulin. ZIKV may be associated with immune-mediated severe thrombocytopenia.