Boerma RS, Bunupuradah T, Dow D, Fokam J, Kariminia A, Lehman D, Kityo C, Musiime V, Palumbo P, Schoffelen A, Sophan S, Zanoni B, Rinke de Wit TF, Calis JCJ, Sigaloff KCE. Multicentre analysis of second-line antiretroviral treatment in HIV-infected children: adolescents at high risk of failure. Journal of the International AIDS Society. 2017 Dec 15;20(20). 21930 p. PMID: 28953325 [PubMed] PMCID: PMC5640308
The number of HIV-infected children and adolescents requiring second-line antiretroviral treatment (ART) is increasing in low- and middle-income countries (LMIC). However, the effectiveness of paediatric second-line ART and potential risk factors for virologic failure are poorly characterized. We performed an aggregate analysis of second-line ART outcomes for children and assessed the need for paediatric third-line ART.