INTIMATE PARTNER VIOLENCE IS ASSOCIATED WITH INCREASED CD4 T-CELL ACTIVATION AMONG HIV-NEGATIVE HIGH-RISK WOMEN.

Kalokhe AS, Ibegbu CC, Kaur SP, Amara RR, Kelley ME, Del Rio C, Stephenson R. INTIMATE PARTNER VIOLENCE IS ASSOCIATED WITH INCREASED CD4 T-CELL ACTIVATION AMONG HIV-NEGATIVE HIGH-RISK WOMEN. Pathogens & immunity. 1(1). 193-213. PMID: 27668294 [PubMed] PMCID: PMC5034930 NIHMSID: NIHMS817049.

Biological pathways mediating the link between intimate partner violence (IPV) and increased HIV risk remain unexplored. We hypothesized that IPV-induced stress negatively affects HIV systemic immune defenses and aimed to evaluate whether IPV was associated with immune profiles linked to HIV susceptibility: CD4 activation and diminished regulatory T-cell (Treg) frequency.