Hyperglycemic clamp-derived disposition index is negatively associated with metabolic syndrome severity in obese subjects.

Shah SS, Ramirez CE, Powers AC, Yu C, Shibao CA, Luther JM. Hyperglycemic clamp-derived disposition index is negatively associated with metabolic syndrome severity in obese subjects. Metabolism: clinical and experimental. 2016 Dec;65(65). 835-42. PMID: 27173462 [PubMed] PMCID: PMC4867079 NIHMSID: NIHMS773710.

Abstract

Metabolic syndrome is associated with insulin resistance and increased future risk of type 2 diabetes. This study investigates the relationship between insulin secretion, insulin resistance and individual metabolic syndrome components in subjects without a prior diagnosis of diabetes.