Moore SC, Matthews CE, Sampson JN, Stolzenberg-Solomon RZ, Zheng W, Cai Q, Tan YT, Chow WH, Ji BT, Liu DK, Xiao Q, Boca SM, Leitzmann MF, Yang G, Xiang YB, Sinha R, Shu XO, Cross AJ. Human metabolic correlates of body mass index. Metabolomics : Official journal of the Metabolomic Society. 2014 Apr 1;10(10). 259-269. PMID: 25254000 [PubMed] PMCID: PMC4169991 NIHMSID: NIHMS535047.
A high body mass index (BMI) is a major risk factor for several chronic diseases, but the biology underlying these associations is not well-understood. Dyslipidemia, inflammation, and elevated levels of growth factors and sex steroid hormones explain some of the increased disease risk, but other metabolic factors not yet identified may also play a role.