Weinberg JB, Yeo TW, Mukemba JP, Florence SM, Volkheimer AD, Wang H, Chen Y, Rubach M, Granger DL, Mwaikambo ED, Anstey NM. Dimethylarginines: endogenous inhibitors of nitric oxide synthesis in children with falciparum malaria. The Journal of infectious diseases. 2014 Sep 15;210(210). 913-22. PMID: 24620026 [PubMed] PMCID: PMC4192051
Nitric oxide (NO) bioavailability is impaired in children and adults with severe falciparum malaria (SM). Asymmetric-dimethylarginine (ADMA) limits NO production by inhibiting NO synthase and is increased in adult SM. The role of ADMA in the pathogenesis of childhood SM is unknown.