Burd EM, Alam MT, Passalacqua KD, Kalokhe AS, Eaton ME, Satola SW, Kraft CS, Read TD. Development of oxacillin resistance in a patient with recurrent Staphylococcus aureus bacteremia. Journal of clinical microbiology. 2014 Aug;52(52). 3114-7. PMID: 24850355 [PubMed] PMCID: PMC4136127
Whole-genome sequencing was used to compare longitudinal isolates of Staphylococcus aureus that developed resistance to oxacillin (MIC up to 16 μg/ml). The mecA gene was absent. A novel 5-bp TATCC frameshift insertion in a gene encoding an ABC transporter similar to that of the teichoic acid translocation ATP-binding protein TagH and a 3-bp GCT nonframeshift insertion in the pdhA pyruvate dehydrogenase gene were detected in the oxacillin-resistant isolates.