Daniel S. Perrien, Ph.D.

Assistant Professor
Medicine, Division of Clinical Pharmacology
Lab Address
2215B Garland Avenue, Room 1225B
Room / Suite
(615) 936-2741

Ph.D. Physiology and Biophysics, 2006, University of Arkansas for Medical Sciences

B.A. Biology, 1998, Hendrix College


Dr. Perrien joined the VCBB in November 2008.  After receiving his Doctorate in Physiology and Biophysics from the University of Arkansas for Medical Sciences, he worked for an orthopaedic tissue engineering company, developing growth factor based drug/device therapies to enhance musculoskeletal repair.  Fracture repair and distraction osteogenesis continue to be major areas of investigation.  In addition, his efforts include mathematical modeling of structure-function relationships in bone, understanding the skeletal response to mechanical load, and endocrine control of bone mass and turnover.

Complete Bibliography

Selected Publications

Research Information

  • Skeletal response to mechanical loading and disuse
  • Fibrodysplasia Ossificans Progressiva (FOP) and Heterotopic Ossification
  • Transforming growth factor receptor 3/Betaglycan in Osteoporosis and Bone Remodeling
  • Musculoskeletal imaging
  • Bone repair and regeneration


  • Computed Tomography and micro-Computed Tomography
  • Finite element modeling
  • Rodent models of fracture repair, distraction osteogenesis, FOP, osteoporosis, heterotopic ossification, disuse osteopenia, and increased loading
  • Biomechanical testing
  • Histomorphometry
  • Immunohistochemistry
  • in situ hybridization
  • Bone cell culture and fluid shear