Mitochondrial DNA Haplogroups and Neurocognitive Impairment During HIV Infection. | Vanderbilt Center for Clinical Cardiovascular Outcomes Research and Trials Evaluation

Hulgan T, Samuels DC, Bush W, Ellis RJ, Letendre SL, Heaton RK, Franklin DR, Straub P, Murdock DG, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Grant I, Kallianpur AR. Mitochondrial DNA Haplogroups and Neurocognitive Impairment During HIV Infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2015 Nov 1;61(61). 1476-84. PMID: 26129753 [PubMed] PMCID: PMC4599391

Abstract

Neurocognitive impairment (NCI) remains an important complication in persons infected with human immunodeficiency virus (HIV). Ancestry-related mitochondrial DNA (mtDNA) haplogroups have been associated with outcomes of HIV infection and combination antiretroviral therapy (CART), and with neurodegenerative diseases. We hypothesize that mtDNA haplogroups are associated with NCI in HIV-infected adults and performed a genetic association study in the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) cohort.