Raffield LM, Cox AJ, Carr JJ, Freedman BI, Hicks PJ, Langefeld CD, Hsu FC, Bowden DW. Analysis of a cardiovascular disease genetic risk score in the Diabetes Heart Study. Acta diabetologica. 2015 Aug;52(52). 743-51. PMID: 25700702 [PubMed] PMCID: PMC4506855 NIHMSID: NIHMS666397.
It remains unclear whether the high cardiovascular disease (CVD) burden in people with type 2 diabetes (T2D) is associated with genetic variants that contribute to CVD in general populations. Recent studies have examined genetic risk scores of single-nucleotide polymorphisms (SNPs) identified by genome-wide association studies for their cumulative contribution to CVD-related traits. Most analyses combined SNPs associated with a single phenotypic class, e.g., lipids. In the present analysis, we examined a more comprehensive risk score comprised of SNPs associated with a broad range of CVD risk phenotypes.