2018
- Juttukonda LJ, Green ER, Lonergan ZR, Heffern MC, Chang CJ, Skaar EP. OxyR regulates the transcriptional response to hydrogen peroxide. Infection and immunity. 2018 Oct 8.
- Gutierrez DB, Gant-Branum RL, Romer CE, Farrow MA, Allen JL, Dahal N, Nei YW, Codreanu SG, Jordan AT, Palmer LD, Sherrod SD, McLean JA, Skaar EP, Norris JL, Caprioli RM. An Integrated, High-Throughput Strategy for Multiomic Systems Level Analysis. Journal of proteome research. 2018 Oct 5;17(10). 3396-3408.
- Pishchany G, Mevers E, Ndousse-Fetter S, Horvath DJ, Paludo CR, Silva-Junior EA, Koren S, Skaar EP, Clardy J, Kolter R. Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen. Proceedings of the National Academy of Sciences of the United States of America. 2018 Oct 2;115(40). 10124-10129.
- Lopez CA, Skaar EP. The Impact of Dietary Transition Metals on Host-Bacterial Interactions. Cell host & microbe. 2018 Jun 13;23(6). 737-748.
- Ayala OD, Wakeman C, Pence IJ, Skaar EP, Mahadevan-Jansen A. Drug-resistant Staphylococcus aureus strains reveal distinct biochemical features with Raman microspectroscopy. ACS infectious diseases. 2018 May 30.
- Lentz CS, Sheldon JR, Crawford LA, Cooper R, Garland M, Amieva MR, Weerapana E, Skaar EP, Bogyo M. Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP). Nature chemical biology. 2018 May 16.
- Cassat JE, Moore JL, Wilson KJ, Stark Z, Prentice BM, Van de Plas R, Perry WJ, Zhang Y, Virostko J, Colvin DC, Rose KL, Judd AM, Reyzer ML, Spraggins JM, Grunenwald CM, Gore JC, Caprioli RM, Skaar EP. Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions. Science translational medicine. 2018 Mar 14;10(432).
- Zackular JP, Skaar EP. The role of zinc and nutritional immunity in Clostridium difficile infection. Gut microbes. 2018 Mar 13.
- Choby JE, Grunenwald CM, Celis AI, Gerdes SY, DuBois JL, Skaar EP. Staphylococcus aureus HemX Modulates Glutamyl-tRNA Reductase Abundance To Regulate Heme Biosynthesis. MBio. 2018 Feb 6;9(1).
- Lojek LJ, Farrand AJ, Weiss A, Skaar EP. Fur regulation of Staphylococcus aureus heme oxygenases is required for heme homeostasis. International journal of medical microbiology : IJMM. 2018 Feb 1.
2017
- Lopez CA, Skaar EP. Crossed Wires: Interspecies Interference Blocks Pathogen Colonization. Cell host & microbe. 2017 Dec 13;22(6). 721-723.
- Aron AT, Heffern MC, Lonergan ZR, Vander Wal MN, Blank BR, Spangler B, Zhang Y, Park HM, Stahl A, Renslo AR, Skaar EP, Chang CJ. In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection. Proceedings of the National Academy of Sciences of the United States of America. 2017 Nov 14.
- Kinsella RL, Lopez J, Palmer LD, Salinas ND, Skaar EP, Tolia NH, Feldman MF. Defining the interaction of the protease CpaA with its type II secretion-chaperone CpaB and its contribution to virulence in Acinetobacter species. The Journal of biological chemistry. 2017 Oct 5.
- Juttukonda LJ, Berends ETM, Zackular JP, Moore JL, Stier MT, Zhang Y, Schmitz JE, Beavers WN, Wijers CD, Gilston BA, Kehl-Fie TE, Atkinson J, Washington MK, Peebles RS, Chazin WJ, Torres VJ, Caprioli RM, Skaar EP. Dietary Manganese Promotes Staphylococcal Infection of the Heart. Cell host & microbe. 2017 Sep 20.
- Peng H, Zhang Y, Palmer LD, Kehl-Fie TE, Skaar EP, Trinidad JC, Giedroc DP. Hydrogen sulfide (H2S) and reactive sulfur species (RSS) impact proteome S-sulfhydration and global virulence regulation in Staphylococcus aureus. ACS infectious diseases. 2017 Aug 29.
- Noto MJ, Burns WJ, Beavers WN, Skaar EP. Mechanisms of pyocyanin toxicity and genetic determinants of resistance in Staphylococcus aureus. Journal of bacteriology. 2017 Jun 12.
- Pulley JM, Shirey-Rice JK, Lavieri RR, Jerome RN, Zaleski NM, Aronoff DM, Bastarache L, Niu X, Holroyd KJ, Roden DM, Skaar EP, Niswender CM, Marnett LJ, Lindsley CW, Ekstrom LB, Bentley AR, Bernard GR, Hong CC, Denny JC. Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics. Assay and drug development technologies. 2017 Apr 5.
- Norris JL, Farrow MA, Gutierrez DB, Palmer LD, Muszynski N, Sherrod SD, Pino JC, Allen JL, Spraggins JM, Lubbock AL, Jordan A, Burns W, Poland JC, Romer C, Manier ML, Nei YW, Prentice BM, Rose KL, Hill S, Van de Plas R, Tsui T, Braman NM, Keller MR, Rutherford SA, Lobdell N, Lopez CF, Lacy DB, McLean JA, Wikswo JP, Skaar EP, Caprioli RM. Integrated, High-Throughput, Multiomics Platform Enables Data-Driven Construction of Cellular Responses and Reveals Global Drug Mechanisms of Action. Journal of proteome research. 2017 Mar 3;16(3). 1364-1375.
- Noto MJ, Becker KW, Boyd KL, Schmidt AM, Skaar EP. RAGE-mediated suppression of IL-10 results in enhanced mortality in a murine model of Acinetobacter baumannii sepsis. Infection and immunity. 2017 Jan 4.
- Peng H, Shen J, Edmonds KA, Luebke JL, Hickey AK, Palmer LD, Chang FJ, Bruce KA, Kehl-Fie TE, Skaar EP, Giedroc DP. Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus. MSphere. 2(3).
- Lojek LJ, Farrand AJ, Wisecaver JH, Blaby-Haas CE, Michel BW, Merchant SS, Rokas A, Skaar EP. Chlamydomonas reinhardtii LFO1 Is an IsdG Family Heme Oxygenase. MSphere. 2(4).
- Garcia YM, Barwinska-Sendra A, Tarrant E, Skaar EP, Waldron KJ, Kehl-Fie TE. A Superoxide Dismutase Capable of Functioning with Iron or Manganese Promotes the Resistance of Staphylococcus aureus to Calprotectin and Nutritional Immunity. PLoS pathogens. 2017 Jan;13(1). e1006125.
2016
- Choby JE, Mike LA, Mashruwala AA, Dutter BF, Dunman PM, Sulikowski GA, Boyd JM, Skaar EP. A Small-Molecule Inhibitor of Iron-Sulfur Cluster Assembly Uncovers a Link between Virulence Regulation and Metabolism in Staphylococcus aureus. Cell chemical biology. 2016 Oct 19.
- Varga MG, Piazuelo MB, Romero-Gallo J, Delgado AG, Suarez G, Whitaker ME, Krishna US, Patel RV, Skaar EP, Wilson KT, Algood HM, Peek RM. TLR9 Activation Suppresses Inflammation in Response to Helicobacter pylori Infection. American journal of physiology. Gastrointestinal and liver physiology. 2016 Oct 6. ajpgi.00175.2016.
- Zackular JP, Moore JL, Jordan AT, Juttukonda LJ, Noto MJ, Nicholson MR, Crews JD, Semler MW, Zhang Y, Ware LB, Washington MK, Chazin WJ, Caprioli RM, Skaar EP. Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection. Nature medicine. 2016 Sep 26.
- Palmer LD, Skaar EP. Transition Metals and Virulence in Bacteria. Annual review of genetics. 2016 Sep 7.
- Surdel MC, Dutter BF, Sulikowski GA, Skaar EP. Bacterial Nitric Oxide Synthase Is Required for the Staphylococcus aureus Response to Heme Stress. ACS infectious diseases. 2016 Aug 12;2(8). 572-578.
- Heilbronner S, Monk IR, Brozyna JR, Heinrichs DE, Skaar EP, Peschel A, Foster TJ. Competing for Iron: Duplication and Amplification of the isd Locus in Staphylococcus lugdunensis HKU09-01 Provides a Competitive Advantage to Overcome Nutritional Limitation. PLoS genetics. 2016 Aug;12(8). e1006246.
- Gilston BA, Skaar EP, Chazin WJ. Binding of transition metals to S100 proteins. Science China. Life sciences. 2016 Jul 19.
- Beavers WN, Skaar EP. Neutrophil generated oxidative stress and protein damage in Staphylococcus aureus. Pathogens and disease. 2016 Jun 27.
- Hendrix AS, Spoonmore TJ, Wilde AD, Putnam NE, Hammer ND, Snyder DJ, Guelcher SA, Skaar EP, Cassat JE. Repurposing the nonsteroidal anti-inflammatory drug diflunisal as an osteoprotective, anti-virulence therapy for Staphylococcus aureus osteomyelitis. Antimicrobial agents and chemotherapy. 2016 Jun 20.
- Nairn BL, Lonergan ZR, Wang J, Braymer JJ, Zhang Y, Calcutt MW, Lisher JP, Gilston BA, Chazin WJ, De Crécy-Lagard V, Giedroc DP, Skaar EP. The Response of Acinetobacter baumannii to Zinc Starvation. Cell host & microbe. 2016 Jun 8;19(6). 826-836.
- Diaz-Ochoa VE, Lam D, Lee CS, Klaus S, Behnsen J, Liu JZ, Chim N, Nuccio SP, Rathi SG, Mastroianni JR, Edwards RA, Jacobo CM, Cerasi M, Battistoni A, Ouellette AJ, Goulding CW, Chazin WJ, Skaar EP, Raffatellu M. Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated Manganese Sequestration. Cell host & microbe. 2016 Jun 8;19(6). 814-825.
- Varga MG, Shaffer CL, Sierra JC, Suarez G, Piazuelo MB, Whitaker ME, Romero-Gallo J, Krishna US, Delgado A, Gomez MA, Good JA, Almqvist F, Skaar EP, Correa P, Wilson KT, Hadjifrangiskou M, Peek RM. Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system. Oncogene. 2016 May 9.
- Spraggins JM, Rizzo DG, Moore JL, Noto MJ, Skaar EP, Caprioli RM. Next-generation technologies for spatial proteomics: Integrating ultra-high speed MALDI-TOF and high mass resolution MALDI FTICR imaging mass spectrometry for protein analysis. Proteomics. 2016 Apr 6.
- Choby J. Skaar E. Heme Synthesis and Acquisition in Bacterial Pathogens 2016 Mar 24; 00204-7.
- Dutter BF, Mike LA, Reid PR, Chong KM, Ramos-Hunter SJ, Skaar EP, Sulikowski GA. Decoupling Activation of Heme Biosynthesis from Anaerobic Toxicity in a Molecule Active in Staphylococcus aureus. ACS chemical biology. 2016 Feb 18.
- Juttukonda LJ, Chazin WJ, Skaar EP. Acinetobacter baumannii Coordinates Urea Metabolism with Metal Import To Resist Host-Mediated Metal Limitation. MBio. 7(5).
- Wakeman CA, Moore JL, Noto MJ, Zhang Y, Singleton MD, Prentice BM, Gilston BA, Doster RS, Gaddy JA, Chazin WJ, Caprioli RM, Skaar EP. The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction. Nature communications. 7. 11951 p.
- Hammer ND, Schurig-Briccio LA, Gerdes SY, Gennis RB, Skaar EP. CtaM Is Required for Menaquinol Oxidase aa3 Function in Staphylococcus aureus. MBio. 7(4).
- Harding CM, Kinsella RL, Palmer LD, Skaar EP, Feldman MF. Medically Relevant Acinetobacter Species Require a Type II Secretion System and Specific Membrane-Associated Chaperones for the Export of Multiple Substrates and Full Virulence. PLoS pathogens. 2016 Jan;12(1). e1005391.
2015
- Wilde AD, Snyder DJ, Putnam NE, Valentino MD, Hammer ND, Lonergan ZR, Hinger SA, Aysanoa EE, Blanchard C, Dunman PM, Wasserman GA, Chen J, Shopsin B, Gilmore MS, Skaar EP, Cassat JE. Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection. PLoS pathogens. 2015 Dec;11(12). e1005341.
- Clark HL, Jhingran A, Sun Y, Vareechon C, De Jesus Carrion S, Skaar EP, Chazin WJ, Calera JA, Hohl TM, Pearlman E. Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits Extracellular Aspergillus fumigatus Hyphal Growth and Corneal Infection. Journal of immunology (Baltimore, Md. : 1950). 2015 Nov 18.
- Streit BR, Kant R, Tokmina-Lukaszewska M, Celis AI, Machovina MM, Skaar EP, Bothner B, DuBois JL. Time-resolved studies of IsdG identify molecular signposts along the non-canonical heme oxygenase pathway. The Journal of biological chemistry. 2015 Nov 3.
- Noto MJ, Boyd KL, Burns WJ, Varga MG, Peek RM, Skaar EP. Toll-like receptor 9 contributes to defense against Acinetobacter baumannii infection. Infection and immunity. 2015 Aug 3.
- Rosario-Cruz Z, Chahal HK, Mike LA, Skaar EP, Boyd JM. Bacillithiol has a role in Fe-S cluster biogenesis in Staphylococcus aureus. Molecular microbiology. 2015 Jul 2.
- Cho H, Jeong DW, Liu Q, Yeo WS, Vogl T, Skaar EP, Chazin WJ, Bae T. Calprotectin Increases the Activity of the SaeRS Two Component System and Murine Mortality during Staphylococcus aureus Infections. PLoS pathogens. 2015 Jul;11(7). e1005026.
- Farrand AJ, Haley KP, Lareau NM, Heilbronner S, McLean JA, Foster T, Skaar EP. An Iron-regulated Autolysin Remodels the Cell Wall to Facilitate Heme Acquisition in Staphylococcus lugdunensis. Infection and immunity. 2015 Jun 29.
- Zackular JP, Chazin WJ, Skaar EP. Nutritional Immunity: S100 Proteins at the Host-Pathogen Interface. The Journal of biological chemistry. 2015 Jun 8.
- Skaar EP, Raffatellu M. Metals in infectious diseases and nutritional immunity. Metallomics : integrated biometal science. 2015 May 28.
- Haley KP, Delgado AG, Piazuelo MB, Mortensen BL, Correa P, Damo SM, Chazin WJ, Skaar EP, Gaddy JA. The human antimicrobial protein calgranulin C (S100A12) participates in control of Helicobacter pylori growth and regulation of virulence. Infection and immunity. 2015 May 11.
- Spraggins JM, Rizzo DG, Moore JL, Rose KL, Hammer ND, Skaar EP, Caprioli RM. MALDI FTICR IMS of Intact Proteins: Using Mass Accuracy to Link Protein Images with Proteomics Data. Journal of the American Society for Mass Spectrometry. 2015 Apr 23.
- Messad N, Prasjnar TK, Lina G, O'Callaghan D, Foster SJ, Renshaw SA, Skaar EP, Bes M, Dunyach-Remy C, Vandenesch F, Sotto A, Lavigne JP. Existence of a colonizing Staphylococcus aureus strain isolated in diabetic foot ulcers. Diabetes. 2015 Apr 21.
- Juttukonda LJ, Skaar EP. Manganese Homeostasis and Utilization in Pathogenic Bacteria. Molecular microbiology. 2015 Apr 21.
- Farrand AJ, Friedman DB, Reniere ML, Ingmer H, Frees D, Skaar EP. Proteomic analyses of iron-responsive, Clp-dependent changes in Staphylococcus aureus. Pathogens and disease. 2015 Apr;73(3).
- D'Orazio M, Mastropasqua MC, Cerasi M, Pacello F, Consalvo A, Chirullo B, Mortensen B, Skaar EP, Ciavardelli D, Pasquali P, Battistoni A. The capability of Pseudomonas aeruginosa to recruit zinc under conditions of limited metal availability is affected by inactivation of the ZnuABC transporter. Metallomics : integrated biometal science. 2015 Mar 9.
- Floyd KA, Moore JL, Eberly AR, Good JA, Shaffer CL, Zaver H, Almqvist F, Skaar EP, Caprioli RM, Hadjifrangiskou M. Adhesive Fiber Stratification in Uropathogenic Escherichia coli Biofilms Unveils Oxygen-Mediated Control of Type 1 Pili. PLoS pathogens. 2015 Mar;11(3). e1004697.
- Gaddy JA, Radin JN, Cullen TW, Chazin WJ, Skaar EP, Trent MS, Algood HM. Helicobacter pylori Resists the Antimicrobial Activity of Calprotectin via Lipid A Modification and Associated Biofilm Formation. MBio. 6(6).
2014
- Mashruwala AA, Pang YY, Rosario-Cruz Z, Chahal HK, Benson MA, Anzaldi-Mike LL, Skaar EP, Torres VJ, Nauseef WM, Boyd JM. Nfu facilitates the maturation of iron-sulfur proteins and participates in virulence in Staphylococcus aureus. Molecular microbiology. 2014 Nov 12.
- Luebke JL, Shen J, Bruce KE, Kehl-Fie TE, Peng H, Skaar EP, Giedroc DP. The CsoR-like sulfurtransferase repressor (CstR) is a persulfide sensor in Staphylococcus aureus. Molecular microbiology. 2014 Oct 16.
- Hammer ND, Cassat JE, Noto MJ, Lojek LJ, Chadha AD, Schmitz JE, Creech CB, Skaar EP. Inter- and Intraspecies Metabolite Exchange Promotes Virulence of Antibiotic-Resistant Staphylococcus aureus. Cell host & microbe. 2014 Oct 8;16(4). 531-537.
- Gaddy JA, Radin JN, Loh JT, Piazuelo MB, Kehl-Fie TE, Delgado AG, Ilca FT, Peek RM, Cover TL, Chazin WJ, Skaar EP, Scott Algood HM. The Host Protein Calprotectin Modulates the Helicobacter pylori cag Type IV Secretion System via Zinc Sequestration. PLoS pathogens. 2014 Oct;10(10). e1004450.
- Becker KW, Skaar EP. Metal limitation and toxicity at the interface between host and pathogen. FEMS microbiology reviews. 2014 Sep 11.
- Achouiti A, Vogl T, Endeman H, Mortensen BL, Laterre PF, Wittebole X, Van Zoelen MA, Zhang Y, Hoogerwerf JJ, Florquin S, Schultz MJ, Grutters JC, Biesma DH, Roth J, Skaar EP, Van 't Veer C, De Vos AF, Van der Poll T. Myeloid-related protein-8/14 facilitates bacterial growth during pneumococcal pneumonia. Thorax. 2014 Sep 1.
- Moore JL, Caprioli RM, Skaar EP. Advanced mass spectrometry technologies for the study of microbial pathogenesis. Current opinion in microbiology. 2014 Jul 2;19C. 45-51.
- Mortensen BL, Rathi S, Chazin WJ, Skaar EP. Acinetobacter baumannii response to host-mediated zinc limitation requires the transcriptional regulator Zur. Journal of bacteriology. 2014 May 9.
- Mike LA, Choby JE, Brinkman PR, Olive LQ, Dutter BF, Ivan SJ, Gibbs CM, Sulikowski GA, Stauff DL, Skaar EP. Two-Component System Cross-Regulation Integrates Bacillus anthracis Response to Heme and Cell Envelope Stress. PLoS pathogens. 2014 Mar;10(3). e1004044.
- Thompson MK, Keithly ME, Goodman MC, Hammer ND, Cook PD, Jagessar KL, Harp J, Skaar EP, Armstrong RN. Structure and Function of the Genomically Encoded Fosfomycin Resistance Enzyme, FosB, from Staphylococcus aureus. Biochemistry. 2014 Feb 4;53(4). 755-65.
- Lin L, Pantapalangkoor P, Tan B, Bruhn K, Ho T, Nielsen T, Skaar EP, Zhang Y, Bai R, Wang A, Doherty TM, Spellberg B. Transferrin iron starvation therapy for lethal bacterial and fungal infections. The Journal of infectious diseases. 2014 Jan 19.
- Wakeman CA, Stauff DL, Zhang Y, Skaar EP. Differential activation of Staphylococcus aureus heme detoxification machinery by heme analogues. Journal of bacteriology. 2014 Jan 17.
2013
- Pishchany G, Sheldon JR, Dickson CF, Alam MT, Read TD, Gell DA, Heinrichs DE, Skaar EP. IsdB-dependent hemoglobin binding is required for acquisition of heme by Staphylococcus aureus. The Journal of infectious diseases. 2013 Dec 13.
- Cassat JE, Skaar EP. Recent advances in experimental models of osteomyelitis. Expert review of anti-infective therapy. 2013 Dec;11(12). 1263-5.
- Hood MI, Uzhachenko R, Boyd K, Skaar EP, Ivanova A. Loss of mitochondrial protein FUS1 augments host resistance to Acinetobacter baumannii infection. Infection and immunity. 2013 Sep 16.
- Kehl-Fie TE, Zhang Y, Moore JL, Farrand AJ, Hood MI, Rathi S, Chazin WJ, Caprioli RM, Skaar EP. MntABC and MntH contribute to systemic Staphylococcus aureus infection by competing with calprotectin for nutrient manganese. Infection and immunity. 2013 Sep;81(9). 3395-405.
- Farrand AJ, Reniere ML, Ingmer H, Frees D, Skaar EP. Regulation of host hemoglobin binding by the Staphylococcus aureus Clp proteolytic system. Journal of bacteriology. 2013 Aug 30.
- Mayfield JA, Hammer ND, Kurker RC, Chen TK, Ojha S, Skaar EP, DuBois JL. The chlorite dismutase (HemQ) from Staphylococcus aureus has a redox-sensitive heme and is associated with the small colony variant phenotype. The Journal of biological chemistry. 2013 Aug 9;288(32). 23488-504.
- Lee K, Boyd KL, Parekh DV, Kehl-Fie TE, Baldwin HS, Brakebusch C, Skaar EP, Boothby M, Zent R. Cdc42 promotes host defenses against fatal infection. Infection and immunity. 2013 Aug;81(8). 2714-23.
- Attia AS, Cassat JE, Aranmolate SO, Zimmerman LJ, Boyd KL, Skaar EP. Analysis of the Staphylococcus aureus abscess proteome identifies antimicrobial host proteins and bacterial stress responses at the host-pathogen interface. Pathogens and disease. 2013 Jul 11.
- Cassat JE, Hammer ND, Campbell JP, Benson MA, Perrien DS, Mrak LN, Smeltzer MS, Torres VJ, Skaar EP. A secreted bacterial protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis. Cell host & microbe. 2013 Jun 12;13(6). 759-72. NIHMSID: NIHMS484604.
- Moore JL, Becker KW, Nicklay JJ, Boyd KL, Skaar EP, Caprioli RM. Imaging mass spectrometry for assessing temporal proteomics: Analysis of calprotectin in Acinetobacter baumannii pulmonary infection. Proteomics. 2013 Jun 11.
- Cassat JE, Skaar EP. Iron in infection and immunity. Cell host & microbe. 2013 May 15;13(5). 509-19. NIHMSID: NIHMS470715.
- Mike LA, Dutter BF, Stauff DL, Moore JL, Vitko NP, Aranmolate O, Kehl-Fie TE, Sullivan S, Reid PR, DuBois JL, Richardson AR, Caprioli RM, Sulikowski GA, Skaar EP. Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America. 2013 May 14;110(20). 8206-11.
- Damo SM, Kehl-Fie TE, Sugitani N, Holt ME, Rathi S, Murphy WJ, Zhang Y, Betz C, Hench L, Fritz G, Skaar EP, Chazin WJ. Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens. Proceedings of the National Academy of Sciences of the United States of America. 2013 Mar 5;110(10). 3841-6.
- Hood MI, Becker KW, Roux CM, Dunman PM, Skaar EP. genetic determinants of intrinsic colistin tolerance in Acinetobacter baumannii. Infection and immunity. 2013 Feb;81(2). 542-51.
- Mortensen BL, Skaar EP. The contribution of nutrient metal acquisition and metabolism to Acinetobacter baumannii survival within the host. Frontiers in cellular and infection microbiology. 3. 95 p.
- Hammer ND, Skaar EP. Powerful genetic resource for the study of methicillin-resistant Staphylococcus aureus. MBio. 4(2).
- Weber BS, Miyata ST, Iwashkiw JA, Mortensen BL, Skaar EP, Pukatzki S, Feldman MF. Genomic and functional analysis of the type VI secretion system in Acinetobacter. PloS one. 8(1). e55142.
- Pishchany G, Haley KP, Skaar EP. Staphylococcus aureus growth using human hemoglobin as an iron source. Journal of visualized experiments : JoVE. NIHMSID: NIHMS514536.
- Weber BS, Miyata ST, Iwashkiw JA, Mortensen BL, Skaar EP, Pukatzki S, Feldman MF. Genomic and functional analysis of the type VI secretion system in Acinetobacter. PloS one. 8(1). e55142.
- Hammer ND, Reniere ML, Cassat JE, Zhang Y, Hirsch AO, Indriati Hood M, Skaar EP. Two heme-dependent terminal oxidases power Staphylococcus aureus organ-specific colonization of the vertebrate host. MBio. 4(4).
2012
- Wakeman CA, Hammer ND, Stauff DL, Attia AS, Anzaldi LL, Dikalov SI, Calcutt MW, Skaar EP. Menaquinone biosynthesis potentiates haem toxicity in Staphylococcus aureus. Molecular microbiology. 2012 Dec;86(6). 1376-92. NIHMSID: NIHMS414112.
- Schmitt J, Joost I, Skaar EP, Herrmann M, Bischoff M. Haemin represses the haemolytic activity of Staphylococcus aureus in an Sae-dependent manner. Microbiology (Reading, England). 2012 Oct;158(Pt 10). 2619-31.
- Mortensen BL, Skaar EP. Host-microbe interactions that shape the pathogenesis of Acinetobacter baumannii infection. Cellular microbiology. 2012 Sep;14(9). 1336-44. NIHMSID: NIHMS515075.
- Hood MI, Skaar EP. Nutritional immunity: transition metals at the pathogen-host interface. Nature reviews. Microbiology. 2012 Aug;10(8). 525-37.
- Attia AS, Schroeder KA, Seeley EH, Wilson KJ, Hammer ND, Colvin DC, Manier ML, Nicklay JJ, Rose KL, Gore JC, Caprioli RM, Skaar EP. Monitoring the inflammatory response to infection through the integration of MALDI IMS and MRI. Cell host & microbe. 2012 Jun 14;11(6). 664-73. NIHMSID: NIHMS381748.
- Damo S, Chazin WJ, Skaar EP, Kehl-Fie TE. Inhibition of bacterial superoxide defense: a new front in the struggle between host and pathogen. Virulence. 2012 May 1;3(3). 325-8.
- Wakeman CA, Skaar EP. Metalloregulation of Gram-positive pathogen physiology. Current opinion in microbiology. 2012 Apr;15(2). 169-74. NIHMSID: NIHMS341569.
- Liu JZ, Jellbauer S, Poe AJ, Ton V, Pesciaroli M, Kehl-Fie TE, Restrepo NA, Hosking MP, Edwards RA, Battistoni A, Pasquali P, Lane TE, Chazin WJ, Vogl T, Roth J, Skaar EP, Raffatellu M. Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut. Cell host & microbe. 2012 Mar 15;11(3). 227-39. NIHMSID: NIHMS361157.
- Haley KP, Skaar EP. A battle for iron: host sequestration and Staphylococcus aureus acquisition. Microbes and infection / Institut Pasteur. 2012 Mar;14(3). 217-27. NIHMSID: NIHMS516297.
- Cassat JE, Skaar EP. Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity. Seminars in immunopathology. 2012 Mar;34(2). 215-35. NIHMSID: NIHMS519859.
- Hammer ND, Skaar EP. The impact of metal sequestration on Staphylococcus aureus metabolism. Current opinion in microbiology. 2012 Feb;15(1). 10-4. NIHMSID: NIHMS339412.
- Pishchany G, Skaar EP. Taste for blood: hemoglobin as a nutrient source for pathogens. PLoS pathogens. 8(3). e1002535.
- Hood MI, Mortensen BL, Moore JL, Zhang Y, Kehl-Fie TE, Sugitani N, Chazin WJ, Caprioli RM, Skaar EP. Identification of an Acinetobacter baumannii zinc acquisition system that facilitates resistance to calprotectin-mediated zinc sequestration. PLoS pathogens. 8(12). e1003068.
- Hood MI, Mortensen BL, Moore JL, Zhang Y, Kehl-Fie TE, Sugitani N, Chazin WJ, Caprioli RM, Skaar EP. Identification of an Acinetobacter baumannii zinc acquisition system that facilitates resistance to calprotectin-mediated zinc sequestration. PLoS pathogens. 8(12). e1003068.
2011
- Krishna Kumar K, Jacques DA, Pishchany G, Caradoc-Davies T, Spirig T, Malmirchegini GR, Langley DB, Dickson CF, Mackay JP, Clubb RT, Skaar EP, Guss JM, Gell DA. Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH. The Journal of biological chemistry. 2011 Nov 4;286(44). 38439-47.
- Anzaldi LL, Skaar EP. The evolution of a superbug: how Staphylococcus aureus overcomes its unique susceptibility to polyamines. Molecular microbiology. 2011 Oct;82(1). 1-3.
- Haley KP, Janson EM, Heilbronner S, Foster TJ, Skaar EP. Staphylococcus lugdunensis IsdG liberates iron from host heme. Journal of bacteriology. 2011 Sep;193(18). 4749-57.
- Kehl-Fie TE, Chitayat S, Hood MI, Damo S, Restrepo N, Garcia C, Munro KA, Chazin WJ, Skaar EP. Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus. Cell host & microbe. 2011 Aug 18;10(2). 158-64. NIHMSID: NIHMS315597.
- Reniere ML, Haley KP, Skaar EP. The flexible loop of Staphylococcus aureus IsdG is required for its degradation in the absence of heme. Biochemistry. 2011 Aug 9;50(31). 6730-7. NIHMSID: NIHMS312898.
- Grossoehme N, Kehl-Fie TE, Ma Z, Adams KW, Cowart DM, Scott RA, Skaar EP, Giedroc DP. Control of copper resistance and inorganic sulfur metabolism by paralogous regulators in Staphylococcus aureus. The Journal of biological chemistry. 2011 Apr 15;286(15). 13522-31.
- Hammer ND, Skaar EP. Molecular mechanisms of Staphylococcus aureus iron acquisition. Annual review of microbiology. 65. 129-47.
- Olson PD, Kuechenmeister LJ, Anderson KL, Daily S, Beenken KE, Roux CM, Reniere ML, Lewis TL, Weiss WJ, Pulse M, Nguyen P, Simecka JW, Morrison JM, Sayood K, Asojo OA, Smeltzer MS, Skaar EP, Dunman PM. Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis. PLoS pathogens. 7(2). e1001287.
2010
- Pishchany G, McCoy AL, Torres VJ, Krause JC, Crowe JE, Fabry ME, Skaar EP. Specificity for human hemoglobin enhances Staphylococcus aureus infection. Cell host & microbe. 2010 Dec 16;8(6). 544-50. NIHMSID: NIHMS256434.
- Anzaldi LL, Skaar EP. Overcoming the heme paradox: heme toxicity and tolerance in bacterial pathogens. Infection and immunity. 2010 Dec;78(12). 4977-89.
- Jacobs AC, Hood I, Boyd KL, Olson PD, Morrison JM, Carson S, Sayood K, Iwen PC, Skaar EP, Dunman PM. Inactivation of phospholipase D diminishes Acinetobacter baumannii pathogenesis. Infection and immunity. 2010 May;78(5). 1952-62.
- Kehl-Fie TE, Skaar EP. Nutritional immunity beyond iron: a role for manganese and zinc. Current opinion in chemical biology. 2010 Apr;14(2). 218-24. NIHMSID: NIHMS159175.
- House DL, Chon CH, Creech CB, Skaar EP, Li D. Miniature on-chip detection of unpurified methicillin-resistant Staphylococcus aureus (MRSA) DNA using real-time PCR. Journal of biotechnology. 2010 Apr 1;146(3). 93-9.
- Torres VJ, Attia AS, Mason WJ, Hood MI, Corbin BD, Beasley FC, Anderson KL, Stauff DL, McDonald WH, Zimmerman LJ, Friedman DB, Heinrichs DE, Dunman PM, Skaar EP. Staphylococcus aureus fur regulates the expression of virulence factors that contribute to the pathogenesis of pneumonia. Infection and immunity. 2010 Apr;78(4). 1618-28.
- Hood MI, Jacobs AC, Sayood K, Dunman PM, Skaar EP. Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. Antimicrobial agents and chemotherapy. 2010 Mar;54(3). 1029-41.
- Attia AS, Benson MA, Stauff DL, Torres VJ, Skaar EP. Membrane damage elicits an immunomodulatory program in Staphylococcus aureus. PLoS pathogens. 2010 Mar;6(3). e1000802.
- Reniere ML, Ukpabi GN, Harry SR, Stec DF, Krull R, Wright DW, Bachmann BO, Murphy ME, Skaar EP. The IsdG-family of haem oxygenases degrades haem to a novel chromophore. Molecular microbiology. 2010 Mar;75(6). 1529-38.
- Skaar EP. The battle for iron between bacterial pathogens and their vertebrate hosts. PLoS pathogens. 6(8). e1000949.
2009
- Pishchany G, Dickey SE, Skaar EP. Subcellular localization of the Staphylococcus aureus heme iron transport components IsdA and IsdB. Infection and immunity. 2009 Jul;77(7). 2624-34.
- Skaar EP. A precious metal heist. Cell host & microbe. 2009 May 8;5(5). 422-4.
- Stauff DL, Skaar EP. Bacillus anthracis HssRS signalling to HrtAB regulates haem resistance during infection. Molecular microbiology. 2009 May;72(3). 763-78. NIHMSID: NIHMS117145.
- Mason WJ, Skaar EP. Assessing the contribution of heme-iron acquisition to Staphylococcus aureus pneumonia using computed tomography. PloS one. 4(8). e6668.
- Stauff DL, Skaar EP. The heme sensor system of Staphylococcus aureus. Contributions to microbiology. 16. 120-35.
2008
- Lee WC, Reniere ML, Skaar EP, Murphy ME. Ruffling of metalloporphyrins bound to IsdG and IsdI, two heme-degrading enzymes in Staphylococcus aureus. The Journal of biological chemistry. 2008 Nov 7;283(45). 30957-63.
- Reniere ML, Skaar EP. Staphylococcus aureus haem oxygenases are differentially regulated by iron and haem. Molecular microbiology. 2008 Sep;69(5). 1304-15. NIHMSID: NIHMS65549.
- Stauff DL, Bagaley D, Torres VJ, Joyce R, Anderson KL, Kuechenmeister L, Dunman PM, Skaar EP. Staphylococcus aureus HrtA is an ATPase required for protection against heme toxicity and prevention of a transcriptional heme stress response. Journal of bacteriology. 2008 May;190(10). 3588-96.
- Corbin BD, Seeley EH, Raab A, Feldmann J, Miller MR, Torres VJ, Anderson KL, Dattilo BM, Dunman PM, Gerads R, Caprioli RM, Nacken W, Chazin WJ, Skaar EP. Metal chelation and inhibition of bacterial growth in tissue abscesses. Science (New York, N.Y.). 2008 Feb 15;319(5865). 962-5.
- Palazzolo-Ballance AM, Reniere ML, Braughton KR, Sturdevant DE, Otto M, Kreiswirth BN, Skaar EP, DeLeo FR. Neutrophil microbicides induce a pathogen survival response in community-associated methicillin-resistant Staphylococcus aureus. Journal of immunology (Baltimore, Md. : 1950). 2008 Jan 1;180(1). 500-9.
2007
- Stauff DL, Torres VJ, Skaar EP. Signaling and DNA-binding activities of the Staphylococcus aureus HssR-HssS two-component system required for heme sensing. The Journal of biological chemistry. 2007 Sep 7;282(36). 26111-21.
- Reniere ML, Torres VJ, Skaar EP. Intracellular metalloporphyrin metabolism in Staphylococcus aureus. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2007 Jun;20(3-4). 333-45.
- Torres VJ, Stauff DL, Pishchany G, Bezbradica JS, Gordy LE, Iturregui J, Anderson KL, Dunman PM, Joyce S, Skaar EP. A Staphylococcus aureus regulatory system that responds to host heme and modulates virulence. Cell host & microbe. 2007 Apr 19;1(2). 109-19. NIHMSID: NIHMS28913.
2006
- Torres VJ, Pishchany G, Humayun M, Schneewind O, Skaar EP. Staphylococcus aureus IsdB is a hemoglobin receptor required for heme iron utilization. Journal of bacteriology. 2006 Dec;188(24). 8421-9.
- Friedman DB, Stauff DL, Pishchany G, Whitwell CW, Torres VJ, Skaar EP. Staphylococcus aureus redirects central metabolism to increase iron availability. PLoS pathogens. 2006 Aug;2(8). e87.
- Skaar EP, Gaspar AH, Schneewind O. Bacillus anthracis IsdG, a heme-degrading monooxygenase. Journal of bacteriology. 2006 Feb;188(3). 1071-80.
2005
- Skaar EP, Lecuyer B, Lenich AG, Lazio MP, Perkins-Balding D, Seifert HS, Karls AC. Analysis of the Piv recombinase-related gene family of Neisseria gonorrhoeae. Journal of bacteriology. 2005 Feb;187(4). 1276-86.
- Wu R, Skaar EP, Zhang R, Joachimiak G, Gornicki P, Schneewind O, Joachimiak A. Staphylococcus aureus IsdG and IsdI, heme-degrading enzymes with structural similarity to monooxygenases. The Journal of biological chemistry. 2005 Jan 28;280(4). 2840-6. NIHMSID: NIHMS143420.
2004
- Skaar EP, Humayun M, Bae T, DeBord KL, Schneewind O. Iron-source preference of Staphylococcus aureus infections. Science (New York, N.Y.). 2004 Sep 10;305(5690). 1626-8.
- Skaar EP, Schneewind O. Iron-regulated surface determinants (Isd) of Staphylococcus aureus: stealing iron from heme. Microbes and infection / Institut Pasteur. 2004 Apr;6(4). 390-7.
- Skaar EP, Gaspar AH, Schneewind O. IsdG and IsdI, heme-degrading enzymes in the cytoplasm of Staphylococcus aureus. The Journal of biological chemistry. 2004 Jan 2;279(1). 436-43.
2003
- Kline KA, Sechman EV, Skaar EP, Seifert HS. Recombination, repair and replication in the pathogenic Neisseriae: the 3 R's of molecular genetics of two human-specific bacterial pathogens. Molecular microbiology. 2003 Oct;50(1). 3-13.
- Mazmanian SK, Skaar EP, Gaspar AH, Humayun M, Gornicki P, Jelenska J, Joachmiak A, Missiakas DM, Schneewind O. Passage of heme-iron across the envelope of Staphylococcus aureus. Science (New York, N.Y.). 2003 Feb 7;299(5608). 906-9.
2002
- Skaar EP, Tobiason DM, Quick J, Judd RC, Weissbach H, Etienne F, Brot N, Seifert HS. The outer membrane localization of the Neisseria gonorrhoeae MsrA/B is involved in survival against reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America. 2002 Jul 23;99(15). 10108-13.
- Skaar EP, Seifert HS. The misidentification of bacterial genes as human cDNAs: was the human D-1 tumor antigen gene acquired from bacteria? Genomics. 2002 May;79(5). 625-7.
- Skaar EP, Lazio MP, Seifert HS. Roles of the recJ and recN genes in homologous recombination and DNA repair pathways of Neisseria gonorrhoeae. Journal of bacteriology. 2002 Feb;184(4). 919-27.
- Hickman JW, Barber RD, Skaar EP, Donohue TJ. Link between the membrane-bound pyridine nucleotide transhydrogenase and glutathione-dependent processes in Rhodobacter sphaeroides. Journal of bacteriology. 2002 Jan;184(2). 400-9.