2023
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Voss K, Sewell AE, Krystofiak ES, Gibson-Corley KN, Young AC, Basham JH, Sugiura A, Arner EN, Beavers WN, Kunkle DE, Dickson ME, Needle GA, Skaar EP, Rathmell WK, Ormseth MJ, Major AS, Rathmell JC. Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus. Science immunology. 2023 Jan 13;8(8). eabq0178. NIHMSID: NIHMS1870489.
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Afzal A, Beavers WN, Skaar EP, Calhoun MC, Richardson KA, Landstreet SR, Cliffel DE, Wright D, Bastarache JA, Ware LB. Ultraviolet light oxidation of fresh hemoglobin eliminates aggregate formation seen in commercially sourced hemoglobin. Blood cells, molecules & diseases. 2023 Jan;98(98). 102699 p.
2022
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Weiss A, Laut CL, Antoine-Reid T, Skaar EP, Schmitz JE. Mobilizing an Institutional Research Enterprise to Support Pandemic Diagnostic Care. Archives of pathology & laboratory medicine. 2022 Dec 20.
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Rivera ES, Weiss A, Migas LG, Freiberg JA, Djambazova KV, Neumann EK, Van de Plas R, Spraggins JM, Skaar EP, Caprioli RM. Imaging mass spectrometry reveals complex lipid distributions across biofilm layers. Journal of mass spectrometry and advances in the clinical lab. 2022 Nov;26(26). 36-46.
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Smith AB, Jenior ML, Keenan O, Hart JL, Specker J, Abbas A, Rangel PC, Di C, Green J, Bustin KA, Gaddy JA, Nicholson MR, Laut C, Kelly BJ, Matthews ML, Evans DR, Van Tyne D, Furth EE, Papin JA, Bushman FD, Erlichman J, Baldassano RN, Silverman MA, Dunny GM, Prentice BM, Skaar EP, Zackular JP. Enterococci enhance Clostridioides difficile pathogenesis. Nature. 2022 Nov;611(611). 780-786. NIHMSID: NIHMS1845454.
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Murdoch CC, Skaar EP. Nutritional immunity: the battle for nutrient metals at the host-pathogen interface. Nature reviews. Microbiology. 2022 Nov;20(20). 657-670.
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Sheldon JR, Himmel LE, Kunkle DE, Monteith AJ, Maloney KN, Skaar EP. Lipocalin-2 is an essential component of the innate immune response to Acinetobacter baumannii infection. PLoS pathogens. 2022 Sep;18(18). e1010809.
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Perry WJ, Grunenwald CM, Van de Plas R, Witten JC, Martin DR, Apte SS, Cassat JE, Pettersson GB, Caprioli RM, Skaar EP, Spraggins JM. Visualizing Staphylococcus aureus pathogenic membrane modification within the host infection environment by multimodal imaging mass spectrometry. Cell chemical biology. 2022 Jul 21;29(29). 1209-1217.e4. NIHMSID: NIHMS1812992.
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Sharman K, Patterson NH, Weiss A, Neumann EK, Guiberson ER, Ryan DJ, Gutierrez DB, Spraggins JM, Van de Plas R, Skaar EP, Caprioli RM. Rapid Multivariate Analysis Approach to Explore Differential Spatial Protein Profiles in Tissue. Journal of proteome research. 2022 Jul 18. NIHMSID: NIHMS1837690.
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Green ER, Fakhoury JN, Monteith AJ, Pi H, Giedroc DP, Skaar EP. Bacterial hydrophilins promote pathogen desiccation tolerance. Cell host & microbe. 2022 Jul 13;30(30). 975-987.e7. NIHMSID: NIHMS1793003.
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Ameka MK, Beavers WN, Shaver CM, Ware LB, Kerchberger VE, Schoenfelt KQ, Sun L, Koyama T, Skaar EP, Becker L, Hasty AH. An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload. International journal of molecular sciences. 2022 Jul 3;23(23).
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Fowler BD, Kose N, Reidy JX, Handal LS, Skaar EP, Crowe JE. Human Monoclonal Antibodies to Escherichia coli Outer Membrane Protein A Porin Domain Cause Aggregation but Do Not Alter Bacterial Burdens in a Murine Sepsis Model. Infection and immunity. 2022 Jun 16;90(90). e0017622.
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Weiss A, Murdoch CC, Edmonds KA, Jordan MR, Monteith AJ, Perera YR, Rodríguez Nassif AM, Petoletti AM, Beavers WN, Munneke MJ, Drury SL, Krystofiak ES, Thalluri K, Wu H, Kruse ARS, DiMarchi RD, Caprioli RM, Spraggins JM, Chazin WJ, Giedroc DP, Skaar EP. Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis. Cell. 2022 Jun 9;185(185). 2148-2163.e27. NIHMSID: NIHMS1797390.
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Guiberson ER, Good CJ, Wexler AG, Skaar EP, Spraggins JM, Caprioli RM. Multimodal Imaging Mass Spectrometry of Murine Gastrointestinal Tract with Retained Luminal Content. Journal of the American Society for Mass Spectrometry. 2022 Jun 1;33(33). 1073-1076. NIHMSID: NIHMS1819205.
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Beavers WN, Munneke MJ, Stackhouse AR, Freiberg JA, Skaar EP. Host Polyunsaturated Fatty Acids Potentiate Aminoglycoside Killing of Staphylococcus aureus. Microbiology spectrum. 2022 Apr 27;10(10). e0276721.
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Rivera-Lugo R, Deng D, Anaya-Sanchez A, Tejedor-Sanz S, Tang E, Reyes Ruiz VM, Smith HB, Titov DV, Sauer JD, Skaar EP, Ajo-Franklin CM, Portnoy DA, Light SH. requires cellular respiration for NAD regeneration and pathogenesis. ELife. 2022 Apr 5;11(11).
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Weiss A, Jackson JK, Shaw LN, Skaar EP. Screening transcriptional connections in using high-throughput transduction of bioluminescent reporter plasmids. Microbiology (Reading, England). 2022 Apr;168(168).
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Pi H, Weiss A, Laut CL, Grunenwald CM, Lin HK, Yi XI, Stauff DL, Skaar EP. An RNA-binding protein acts as a major post-transcriptional modulator in Bacillus anthracis. Nature communications. 2022 Mar 21;13(13). 1491 p.
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Monteith AJ, Miller JM, Beavers WN, Juttukonda LJ, Skaar EP. Increased Dietary Manganese Impairs Neutrophil Extracellular Trap Formation Rendering Neutrophils Ineffective at Combating Staphylococcus aureus. Infection and immunity. 2022 Mar 17;90(90). e0068521.
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Skaar EP, Echols R, Matsunaga Y, Menon A, Portsmouth S. Iron serum levels and iron homeostasis parameters in patients with nosocomial pneumonia treated with cefiderocol: post hoc analysis of the APEKS-NP study. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2022 Mar;41(41). 467-476.
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Monteith AJ, Miller JM, Beavers WN, Maloney KN, Seifert EL, Hajnoczky G, Skaar EP. Mitochondrial Calcium Uniporter Affects Neutrophil Bactericidal Activity during Staphylococcus aureus Infection. Infection and immunity. 2022 Feb 17;90(90). e0055121.
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Laut CL, Leasure CS, Pi H, Carlin SM, Chu ML, Hillebrand GH, Lin HK, Yi XI, Stauff DL, Skaar EP. DnaJ and ClpX Are Required for HitRS and HssRS Two-Component System Signaling in Bacillus anthracis. Infection and immunity. 2022 Jan 25;90(90). e0056021.
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Monteith AJ, Miller JM, Williams JM, Voss K, Rathmell JC, Crofford LJ, Skaar EP. Altered Mitochondrial Homeostasis during Systemic Lupus Erythematosus Impairs Neutrophil Extracellular Trap Formation Rendering Neutrophils Ineffective at Combating . Journal of immunology (Baltimore, Md. : 1950). 2022 Jan 15;208(208). 454-463. NIHMSID: NIHMS1757204.
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Cuevas S, Liu QK, Qian H, Joffe ME, Calvitti K, Schladt M, Skaar EP, Oliver KH. How to design an art-science program? Self-reported benefits for artists and scientists in the VI4 artist-in-residence program. PloS one. 17(17). e0279183.
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Munneke MJ, Skaar EP. Ornithine supports C. difficile gut carriage. Nature metabolism. 2022 Jan;4(4). 7-8.
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Wijers CDM, Pham L, Douglass MV, Skaar EP, Palmer LD, Noto MJ. Gram-negative bacteria act as a reservoir for aminoglycoside antibiotics that interact with host factors to enhance bacterial killing in a mouse model of pneumonia. FEMS microbes. 3(3). xtac016.
2021
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Bisht K, Moore JL, Caprioli RM, Skaar EP, Wakeman CA. Impact of temperature-dependent phage expression on Pseudomonas aeruginosa biofilm formation. NPJ biofilms and microbiomes. 2021 Dec 16;7(7). 22 p.
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Weiss A, Lopez CA, Beavers WN, Rodriguez J, Skaar EP. strain-dependent and strain-independent adaptations to a microaerobic environment. Microbial genomics. 2021 Dec;7(7).
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Behnsen J, Zhi H, Aron AT, Subramanian V, Santus W, Lee MH, Gerner RR, Petras D, Liu JZ, Green KD, Price SL, Camacho J, Hillman H, Tjokrosurjo J, Montaldo NP, Hoover EM, Treacy-Abarca S, Gilston BA, Skaar EP, Chazin WJ, Garneau-Tsodikova S, Lawrenz MB, Perry RD, Nuccio SP, Dorrestein PC, Raffatellu M. Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut. Nature communications. 2021 Dec 1;12(12). 7016 p.
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Drury SL, Miller AR, Laut CL, Walter AB, Bennett MR, Su M, Bai M, Jing B, Joseph SB, Metzger EJ, Bane CE, Black CC, Macdonald MT, Dutter BF, Romaine IM, Waterson AG, Sulikowski GA, Jansen ED, Crowe JE, Sciotti RJ, Skaar EP. Simultaneous Exposure to Intracellular and Extracellular Photosensitizers for the Treatment of Staphylococcus aureus Infections. Antimicrobial agents and chemotherapy. 2021 Nov 17;65(65). e0091921.
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Monteith AJ, Miller JM, Maxwell CN, Chazin WJ, Skaar EP. Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens. Science advances. 2021 Sep 10;7(7). eabj2101.
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Skaar EP. Imaging Infection Across Scales of Size: From Whole Animals to Single Molecules. Annual review of microbiology. 2021 Aug 3.
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Beavers WN, DuMont AL, Monteith AJ, Maloney KN, Tallman KA, Weiss A, Christian AH, Toste FD, Chang CJ, Porter NA, Torres VJ, Skaar EP. peptide methionine sulfoxide reductases protect from human whole blood killing. Infection and immunity. 2021 May 17.
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Klopfenstein N, Cassat JE, Monteith A, Miller A, Drury S, Skaar E, Serezani CH. Murine Models for Staphylococcal Infection. Current protocols. 2021 Mar;1(1). e52. NIHMSID: NIHMS1665816.
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Parnell JM, Fazili I, Bloch SC, Lacy DB, Garcia-Lopez VA, Bernard R, Skaar EP, Edwards KM, Nicholson MR. Two-step Testing for Clostridioides Difficile is Inadequate in Differentiating Infection From Colonization in Children. Journal of pediatric gastroenterology and nutrition. 2021 Mar 1;72(72). 378-383.
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Guiberson ER, Weiss A, Ryan DJ, Monteith AJ, Sharman K, Gutierrez DB, Perry WJ, Caprioli RM, Skaar EP, Spraggins JM. Spatially Targeted Proteomics of the Host-Pathogen Interface during Staphylococcal Abscess Formation. ACS infectious diseases. 2021 Jan 8;7(7). 101-113. NIHMSID: NIHMS1654501.
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Bozhanova NG, Calcutt MW, Beavers WN, Brown BP, Skaar EP, Meiler J. Lipocalin Blc is a potential heme-binding protein. FEBS letters. 2021 Jan;595(595). 206-219.
2020
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Laut CL, Perry WJ, Metzger AL, Weiss A, Stauff DL, Walker S, Caprioli RM, Skaar EP. Bacillus anthracis Responds to Targocil-Induced Envelope Damage through EdsRS Activation of Cardiolipin Synthesis. MBio. 2020 Dec 31;11(11).
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Juttukonda LJ, Beavers WN, Unsihuay D, Kim K, Pishchany G, Horning KJ, Weiss A, Al-Tameemi H, Boyd JM, Sulikowski GA, Bowman AB, Skaar EP. A Small-Molecule Modulator of Metal Homeostasis in Gram-Positive Pathogens. MBio. 2020 Dec 27;11(11).
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Walsh BJC, Wang J, Edmonds KA, Palmer LD, Zhang Y, Trinidad JC, Skaar EP, Giedroc DP. The Response of to Hydrogen Sulfide Reveals Two Independent Persulfide-Sensing Systems and a Connection to Biofilm Regulation. MBio. 2020 Dec 23;11(11).
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Zackular JP, Knippel RJ, Lopez CA, Beavers WN, Maxwell CN, Chazin WJ, Skaar EP. ZupT Facilitates Clostridioides difficile Resistance to Host-Mediated Nutritional Immunity. MSphere. 2020 Dec 11;5(5).
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Sheldon JR, Skaar EP. Acinetobacter baumannii can use multiple siderophores for iron acquisition, but only acinetobactin is required for virulence. PLoS pathogens. 2020 Dec;16(16). e1008995.
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Skaar EP, Zackular JP. Editorial overview: Microbe-microbe interactions: the enemy of my enemy is my friend. Current opinion in microbiology. 2020 Dec;53(53). iii-v.
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Hood-Pishchany MI, Pham L, Wijers CD, Burns WJ, Boyd KL, Palmer LD, Skaar EP, Noto MJ. Broad-spectrum suppression of bacterial pneumonia by aminoglycoside-propagated Acinetobacter baumannii. PLoS pathogens. 2020 Dec;16(16). e1008374.
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Pi H, Chu ML, Ivan SJ, Latario CJ, Toth AM, Carlin SM, Hillebrand GH, Lin HK, Reppart JD, Stauff DL, Skaar EP. Directed evolution reveals the mechanism of HitRS signaling transduction in Bacillus anthracis. PLoS pathogens. 2020 Dec;16(16). e1009148.
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Perry WJ, Weiss A, Van de Plas R, Spraggins JM, Caprioli RM, Skaar EP. Integrated molecular imaging technologies for investigation of metals in biological systems: A brief review. Current opinion in chemical biology. 2020 Dec;55(55). 127-135. NIHMSID: NIHMS1564217.
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Ray A, Edmonds KA, Palmer LD, Skaar EP, Giedroc DP. Glucose-Induced Biofilm Accessory Protein A (GbaA) Is a Monothiol-Dependent Electrophile Sensor. Biochemistry. 2020 Aug 11;59(59). 2882-2895.
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Syring KE, Bosma KJ, Goleva SB, Singh K, Oeser JK, Lopez CA, Skaar EP, McGuinness OP, Davis LK, Powell DR, O'Brien RM. Potential positive and negative consequences of ZnT8 inhibition. The Journal of endocrinology. 2020 Aug;246(246). 189-205. NIHMSID: NIHMS1602812.
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Lonergan ZR, Palmer LD, Skaar EP. Histidine Utilization Is a Critical Determinant of Pathogenesis. Infection and immunity. 2020 Jun 22;88(88).
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Knippel RJ, Wexler AG, Miller JM, Beavers WN, Weiss A, De Crécy-Lagard V, Edmonds KA, Giedroc DP, Skaar EP. Clostridioides difficile Senses and Hijacks Host Heme for Incorporation into an Oxidative Stress Defense System. Cell host & microbe. 2020 Jun 7.
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Lopez CA, McNeely TP, Nurmakova K, Beavers WN, Skaar EP. Clostridioides difficile proline fermentation in response to commensal clostridia. Anaerobe. 2020 Jun;63(63). 102210 p.
2019
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Bennett MR, Dong J, Bombardi RG, Soto C, Parrington HM, Nargi RS, Schoeder CT, Nagel MB, Schey KL, Meiler J, Skaar EP, Crowe JE. Human Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis. MBio. 2019 Dec 22;10(10).
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Walter AB, Simpson J, Jenkins JL, Skaar EP, Jansen ED. Optimization of Optical Parameters for Improved Photodynamic Therapy of Staphylococcus aureus Using Endogenous Coproporphyrin III. Photodiagnosis and photodynamic therapy. 2019 Dec 19. 101624 p.
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Lopez CA, Beavers WN, Weiss A, Knippel RJ, Zackular JP, Chazin W, Skaar EP. The Immune Protein Calprotectin Impacts Clostridioides difficile Metabolism through Zinc Limitation. MBio. 2019 Dec 19;10(10).
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Choby JE, Skaar EP. Staphylococcus aureus Coproporphyrinogen III Oxidase Is Required for Aerobic and Anaerobic Heme Synthesis. MSphere. 2019 Dec 10;4(4).
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Green ER, Juttukonda LJ, Skaar EP. The manganese-responsive transcriptional regulator MumR protects from oxidative stress. Infection and immunity. 2019 Dec 2.
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Beavers WN, Monteith AJ, Amarnath V, Mernaugh RL, Roberts LJ, Chazin WJ, Davies SS, Skaar EP. Arachidonic Acid Kills Staphylococcus aureus through a Lipid Peroxidation Mechanism. MBio. 2019 Dec 1;10(10).
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Hesse LE, Lonergan ZR, Beavers WN, Skaar EP. The Acinetobacter baumannii Znu System Overcomes Host-Imposed Nutrient Zinc Limitation. Infection and immunity. 2019 Dec;87(87).
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Lonergan ZR, Skaar EP. Nutrient Zinc at the Host-Pathogen Interface. Trends in biochemical sciences. 2019 Dec;44(44). 1041-1056. NIHMSID: NIHMS1535025.
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Perry WJ, Spraggins JM, Sheldon JR, Grunenwald CM, Heinrichs DE, Cassat JE, Skaar EP, Caprioli RM. exhibits heterogeneous siderophore production within the vertebrate host. Proceedings of the National Academy of Sciences of the United States of America. 2019 Oct 29;116(116). 21980-21982.
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Jordan MR, Wang J, Weiss A, Skaar EP, Capdevila DA, Giedroc DP. Mechanistic Insights into the Metal-Dependent Activation of Zn-Dependent Metallochaperones. Inorganic chemistry. 2019 Oct 21;58(58). 13661-13672.
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Wang J, Lonergan ZR, Gonzalez-Gutierrez G, Nairn BL, Maxwell CN, Zhang Y, Andreini C, Karty JA, Chazin WJ, Trinidad JC, Skaar EP, Giedroc DP. Multi-metal Restriction by Calprotectin Impacts De Novo Flavin Biosynthesis in Acinetobacter baumannii. Cell chemical biology. 2019 May 16;26(26). 745-755.e7. NIHMSID: NIHMS1523343.
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Sheldon JR, Skaar EP. Metals as phagocyte antimicrobial effectors. Current opinion in immunology. 2019 May 4;60(60). 1-9.
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Noto JM, Zackular JP, Varga MG, Delgado A, Romero-Gallo J, Scholz MB, Piazuelo MB, Skaar EP, Peek RM. Modification of the Gastric Mucosal Microbiota by a Strain-Specific Helicobacter pylori Oncoprotein and Carcinogenic Histologic Phenotype. MBio. 2019 May;10(10).
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Bennett MR, Bombardi RG, Kose N, Parrish EH, Nagel MB, Petit RA, Read TD, Schey KL, Thomsen IP, Skaar EP, Crowe JE. Human mAbs to Staphylococcus aureus IsdA Provide Protection Through Both Heme-Blocking and Fc-Mediated Mechanisms. The Journal of infectious diseases. 2019 Apr 8;219(219). 1264-1273.
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Choby JE, Monteith AJ, Himmel LE, Margaritis P, Shirey-Rice JK, Pruijssers A, Jerome RN, Pulley J, Skaar EP. A Phenome-Wide Association Study Uncovers a Pathological Role of Coagulation Factor X during Infection. Infection and immunity. 2019 Apr;87(87).
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Grunenwald CM, Choby JE, Juttukonda LJ, Beavers WN, Weiss A, Torres VJ, Skaar EP. Manganese Detoxification by MntE Is Critical for Resistance to Oxidative Stress and Virulence of Staphylococcus aureus. MBio. 2019 Feb 26;10(10).
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Palmer LD, Skaar EP. Cuts Both Ways: Proteases Modulate Virulence of Enterohemorrhagic Escherichia coli. MBio. 2019 Feb 26;10(10).
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Lonergan ZR, Nairn BL, Wang J, Hsu YP, Hesse LE, Beavers WN, Chazin WJ, Trinidad JC, VanNieuwenhze MS, Giedroc DP, Skaar EP. An Acinetobacter baumannii, Zinc-Regulated Peptidase Maintains Cell Wall Integrity during Immune-Mediated Nutrient Sequestration. Cell reports. 2019 Feb 19;26(26). 2009-2018.e6. NIHMSID: NIHMS1014413.
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Williams JC, Sheldon JR, Imlay HD, Dutter BF, Draelos MM, Skaar EP, Sulikowski GA. Synthesis of the Siderophore Coelichelin and Its Utility as a Probe in the Study of Bacterial Metal Sensing and Response. Organic letters. 2019 Feb 1;21(21). 679-682. NIHMSID: NIHMS1009635.
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Maseda D, Zackular JP, Trindade B, Kirk L, Roxas JL, Rogers LM , Washington MK , Du L, Koyama T, Viswanathan VK, Vedantam G, Schloss PD, Crofford LJ, Skaar EP, Aronoff DM. Nonsteroidal Anti-inflammatory Drugs Alter the Microbiota and Exacerbate Colitis while Dysregulating the Inflammatory Response. MBio. 2019 Jan 8;10(10).
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Palmer LD, Green ER, Sheldon JR, Skaar EP. Assessing Acinetobacter baumannii Virulence and Persistence in a Murine Model of Lung Infection. Methods in molecular biology (Clifton, N.J.). 1946(1946). 289-305. NIHMSID: NIHMS1016173.
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Kozlyuk N, Monteith AJ, Garcia V, Damo SM, Skaar EP, Chazin WJ. S100 Proteins in the Innate Immune Response to Pathogens. Methods in molecular biology (Clifton, N.J.). 1929(1929). 275-290. NIHMSID: NIHMS1017257.
2018
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Barber MF. Molecular Basis for the Evolution of Species-Specific Hemoglobin Capture by Staphylococcus aureus. MBio. 2018 Dec 20;9(9).
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Grunenwald CM, Bennett MR, Skaar EP. Nonconventional Therapeutics against Staphylococcus aureus. Microbiology spectrum. 2018 Dec;6(6). NIHMSID: NIHMS998175.
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Knippel RJ, Zackular JP, Moore JL, Celis AI, Weiss A, Washington MK, DuBois JL, Caprioli RM, Skaar EP. Heme sensing and detoxification by HatRT contributes to pathogenesis during Clostridium difficile infection. PLoS pathogens. 2018 Dec;14(14). e1007486.
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Juttukonda LJ, Green ER, Lonergan ZR, Heffern MC, Chang CJ, Skaar EP. OxyR regulates the transcriptional response to hydrogen peroxide. Infection and immunity. 2018 Oct 8.
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Gutierrez DB, Gant-Branum RL, Romer CE, Farrow MA, Allen JL, Dahal N, Nei YW, Codreanu SG, Jordan AT, Palmer LD, Sherrod SD, McLean JA, Skaar EP, Norris JL, Caprioli RM. An Integrated, High-Throughput Strategy for Multiomic Systems Level Analysis. Journal of proteome research. 2018 Oct 5;17(17). 3396-3408.
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Pishchany G, Mevers E, Ndousse-Fetter S, Horvath DJ, Paludo CR, Silva-Junior EA, Koren S, Skaar EP, Clardy J, Kolter R. Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen. Proceedings of the National Academy of Sciences of the United States of America. 2018 Oct 2;115(115). 10124-10129.
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Lopez CA, Skaar EP. The Impact of Dietary Transition Metals on Host-Bacterial Interactions. Cell host & microbe. 2018 Jun 13;23(23). 737-748.
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Ayala OD, Wakeman C, Pence IJ, Skaar EP, Mahadevan-Jansen A. Drug-resistant Staphylococcus aureus strains reveal distinct biochemical features with Raman microspectroscopy. ACS infectious diseases. 2018 May 30.
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Lentz CS, Sheldon JR, Crawford LA, Cooper R, Garland M, Amieva MR, Weerapana E, Skaar EP, Bogyo M. Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP). Nature chemical biology. 2018 May 16.
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Cassat JE, Moore JL, Wilson KJ, Stark Z, Prentice BM, Van de Plas R, Perry WJ, Zhang Y, Virostko J, Colvin DC, Rose KL, Judd AM, Reyzer ML, Spraggins JM, Grunenwald CM, Gore JC, Caprioli RM, Skaar EP. Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions. Science translational medicine. 2018 Mar 14;10(10).
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Zackular JP, Skaar EP. The role of zinc and nutritional immunity in Clostridium difficile infection. Gut microbes. 2018 Mar 13.
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Choby JE, Grunenwald CM, Celis AI, Gerdes SY, DuBois JL, Skaar EP. Staphylococcus aureus HemX Modulates Glutamyl-tRNA Reductase Abundance To Regulate Heme Biosynthesis. MBio. 2018 Feb 6;9(9).
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Lojek LJ, Farrand AJ, Weiss A, Skaar EP. Fur regulation of Staphylococcus aureus heme oxygenases is required for heme homeostasis. International journal of medical microbiology : IJMM. 2018 Feb 1.
2017
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Lopez CA, Skaar EP. Crossed Wires: Interspecies Interference Blocks Pathogen Colonization. Cell host & microbe. 2017 Dec 13;22(22). 721-723.
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Aron AT, Heffern MC, Lonergan ZR, Vander Wal MN, Blank BR, Spangler B, Zhang Y, Park HM, Stahl A, Renslo AR, Skaar EP, Chang CJ. In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection. Proceedings of the National Academy of Sciences of the United States of America. 2017 Nov 14.
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Kinsella RL, Lopez J, Palmer LD, Salinas ND, Skaar EP, Tolia NH, Feldman MF. Defining the interaction of the protease CpaA with its type II secretion-chaperone CpaB and its contribution to virulence in Acinetobacter species. The Journal of biological chemistry. 2017 Oct 5.
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Juttukonda LJ, Berends ETM, Zackular JP, Moore JL, Stier MT, Zhang Y, Schmitz JE, Beavers WN, Wijers CD, Gilston BA, Kehl-Fie TE, Atkinson J, Washington MK, Peebles RS, Chazin WJ, Torres VJ, Caprioli RM, Skaar EP. Dietary Manganese Promotes Staphylococcal Infection of the Heart. Cell host & microbe. 2017 Sep 20.
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Peng H, Zhang Y, Palmer LD, Kehl-Fie TE, Skaar EP, Trinidad JC, Giedroc DP. Hydrogen sulfide (H2S) and reactive sulfur species (RSS) impact proteome S-sulfhydration and global virulence regulation in Staphylococcus aureus. ACS infectious diseases. 2017 Aug 29.
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Surdel MC, Horvath DJ, Lojek LJ, Fullen AR, Simpson J, Dutter BF, Salleng KJ, Ford JB, Jenkins JL, Nagarajan R, Teixeira PL, Albertolle M, Georgiev IS, Jansen ED, Sulikowski GA, Lacy DB, Dailey HA, Skaar EP. Antibacterial photosensitization through activation of coproporphyrinogen oxidase. Proceedings of the National Academy of Sciences of the United States of America. 2017 Jul 24.
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Noto MJ, Burns WJ, Beavers WN, Skaar EP. Mechanisms of pyocyanin toxicity and genetic determinants of resistance in Staphylococcus aureus. Journal of bacteriology. 2017 Jun 12.
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Pulley JM, Shirey-Rice JK, Lavieri RR, Jerome RN, Zaleski NM, Aronoff DM, Bastarache L, Niu X, Holroyd KJ, Roden DM, Skaar EP, Niswender CM, Marnett LJ, Lindsley CW, Ekstrom LB, Bentley AR, Bernard GR, Hong CC, Denny JC. Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics. Assay and drug development technologies. 2017 Apr 5.
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Norris JL, Farrow MA, Gutierrez DB, Palmer LD, Muszynski N, Sherrod SD, Pino JC, Allen JL, Spraggins JM, Lubbock AL, Jordan A, Burns W, Poland JC, Romer C, Manier ML, Nei YW, Prentice BM, Rose KL, Hill S, Van de Plas R, Tsui T, Braman NM, Keller MR, Rutherford SA, Lobdell N, Lopez CF, Lacy DB, McLean JA, Wikswo JP, Skaar EP, Caprioli RM. Integrated, High-Throughput, Multiomics Platform Enables Data-Driven Construction of Cellular Responses and Reveals Global Drug Mechanisms of Action. Journal of proteome research. 2017 Mar 3;16(16). 1364-1375.
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Noto MJ, Becker KW, Boyd KL, Schmidt AM, Skaar EP. RAGE-mediated suppression of IL-10 results in enhanced mortality in a murine model of Acinetobacter baumannii sepsis. Infection and immunity. 2017 Jan 4.
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Peng H, Shen J, Edmonds KA, Luebke JL, Hickey AK, Palmer LD, Chang FJ, Bruce KA, Kehl-Fie TE, Skaar EP, Giedroc DP. Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus. MSphere. 2(2).
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Lojek LJ, Farrand AJ, Wisecaver JH, Blaby-Haas CE, Michel BW, Merchant SS, Rokas A, Skaar EP. Chlamydomonas reinhardtii LFO1 Is an IsdG Family Heme Oxygenase. MSphere. 2(2).
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Garcia YM, Barwinska-Sendra A, Tarrant E, Skaar EP, Waldron KJ, Kehl-Fie TE. A Superoxide Dismutase Capable of Functioning with Iron or Manganese Promotes the Resistance of Staphylococcus aureus to Calprotectin and Nutritional Immunity. PLoS pathogens. 2017 Jan;13(13). e1006125.
2016
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Choby JE, Mike LA, Mashruwala AA, Dutter BF, Dunman PM, Sulikowski GA, Boyd JM, Skaar EP. A Small-Molecule Inhibitor of Iron-Sulfur Cluster Assembly Uncovers a Link between Virulence Regulation and Metabolism in Staphylococcus aureus. Cell chemical biology. 2016 Oct 19.
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Varga MG, Piazuelo MB, Romero-Gallo J, Delgado AG, Suarez G, Whitaker ME, Krishna US, Patel RV, Skaar EP, Wilson KT, Algood HM, Peek RM. TLR9 Activation Suppresses Inflammation in Response to Helicobacter pylori Infection. American journal of physiology. Gastrointestinal and liver physiology. 2016 Oct 6. ajpgi.00175.2016.
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Zackular JP, Moore JL, Jordan AT, Juttukonda LJ, Noto MJ, Nicholson MR, Crews JD, Semler MW, Zhang Y, Ware LB, Washington MK, Chazin WJ, Caprioli RM, Skaar EP. Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection. Nature medicine. 2016 Sep 26.
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Palmer LD, Skaar EP. Transition Metals and Virulence in Bacteria. Annual review of genetics. 2016 Sep 7.
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Surdel MC, Dutter BF, Sulikowski GA, Skaar EP. Bacterial Nitric Oxide Synthase Is Required for the Staphylococcus aureus Response to Heme Stress. ACS infectious diseases. 2016 Aug 12;2(2). 572-578.
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Heilbronner S, Monk IR, Brozyna JR, Heinrichs DE, Skaar EP, Peschel A, Foster TJ. Competing for Iron: Duplication and Amplification of the isd Locus in Staphylococcus lugdunensis HKU09-01 Provides a Competitive Advantage to Overcome Nutritional Limitation. PLoS genetics. 2016 Aug;12(12). e1006246.
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Gilston BA, Skaar EP, Chazin WJ. Binding of transition metals to S100 proteins. Science China. Life sciences. 2016 Jul 19.
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Beavers WN, Skaar EP. Neutrophil generated oxidative stress and protein damage in Staphylococcus aureus. Pathogens and disease. 2016 Jun 27.
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Hendrix AS, Spoonmore TJ, Wilde AD, Putnam NE, Hammer ND, Snyder DJ, Guelcher SA, Skaar EP, Cassat JE. Repurposing the nonsteroidal anti-inflammatory drug diflunisal as an osteoprotective, anti-virulence therapy for Staphylococcus aureus osteomyelitis. Antimicrobial agents and chemotherapy. 2016 Jun 20.
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Nairn BL, Lonergan ZR, Wang J, Braymer JJ, Zhang Y, Calcutt MW, Lisher JP, Gilston BA, Chazin WJ, De Crécy-Lagard V, Giedroc DP, Skaar EP. The Response of Acinetobacter baumannii to Zinc Starvation. Cell host & microbe. 2016 Jun 8;19(19). 826-836.
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Diaz-Ochoa VE, Lam D, Lee CS, Klaus S, Behnsen J, Liu JZ, Chim N, Nuccio SP, Rathi SG, Mastroianni JR, Edwards RA, Jacobo CM, Cerasi M, Battistoni A, Ouellette AJ, Goulding CW, Chazin WJ, Skaar EP, Raffatellu M. Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated Manganese Sequestration. Cell host & microbe. 2016 Jun 8;19(19). 814-825.
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Varga MG, Shaffer CL, Sierra JC, Suarez G, Piazuelo MB, Whitaker ME, Romero-Gallo J, Krishna US, Delgado A, Gomez MA, Good JA, Almqvist F, Skaar EP, Correa P, Wilson KT, Hadjifrangiskou M, Peek RM. Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system. Oncogene. 2016 May 9.
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Spraggins JM, Rizzo DG, Moore JL, Noto MJ, Skaar EP, Caprioli RM. Next-generation technologies for spatial proteomics: Integrating ultra-high speed MALDI-TOF and high mass resolution MALDI FTICR imaging mass spectrometry for protein analysis. Proteomics. 2016 Apr 6.
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Choby J. Skaar E. Heme Synthesis and Acquisition in Bacterial Pathogens 2016 Mar 24. 00204-7.
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Dutter BF, Mike LA, Reid PR, Chong KM, Ramos-Hunter SJ, Skaar EP, Sulikowski GA. Decoupling Activation of Heme Biosynthesis from Anaerobic Toxicity in a Molecule Active in Staphylococcus aureus. ACS chemical biology. 2016 Feb 18.
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Wakeman CA, Moore JL, Noto MJ, Zhang Y, Singleton MD, Prentice BM, Gilston BA, Doster RS, Gaddy JA, Chazin WJ, Caprioli RM, Skaar EP. The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction. Nature communications. 7(7). 11951 p.
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Hammer ND, Schurig-Briccio LA, Gerdes SY, Gennis RB, Skaar EP. CtaM Is Required for Menaquinol Oxidase aa3 Function in Staphylococcus aureus. MBio. 7(7).
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Harding CM, Kinsella RL, Palmer LD, Skaar EP, Feldman MF. Medically Relevant Acinetobacter Species Require a Type II Secretion System and Specific Membrane-Associated Chaperones for the Export of Multiple Substrates and Full Virulence. PLoS pathogens. 2016 Jan;12(12). e1005391.
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Juttukonda LJ, Chazin WJ, Skaar EP. Acinetobacter baumannii Coordinates Urea Metabolism with Metal Import To Resist Host-Mediated Metal Limitation. MBio. 7(7).
2015
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Wilde AD, Snyder DJ, Putnam NE, Valentino MD, Hammer ND, Lonergan ZR, Hinger SA, Aysanoa EE, Blanchard C, Dunman PM, Wasserman GA, Chen J, Shopsin B, Gilmore MS, Skaar EP, Cassat JE. Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection. PLoS pathogens. 2015 Dec;11(11). e1005341.
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Clark HL, Jhingran A, Sun Y, Vareechon C, De Jesus Carrion S, Skaar EP, Chazin WJ, Calera JA, Hohl TM, Pearlman E. Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits Extracellular Aspergillus fumigatus Hyphal Growth and Corneal Infection. Journal of immunology (Baltimore, Md. : 1950). 2015 Nov 18.
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Streit BR, Kant R, Tokmina-Lukaszewska M, Celis AI, Machovina MM, Skaar EP, Bothner B, DuBois JL. Time-resolved studies of IsdG identify molecular signposts along the non-canonical heme oxygenase pathway. The Journal of biological chemistry. 2015 Nov 3.
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Noto MJ, Boyd KL, Burns WJ, Varga MG, Peek RM, Skaar EP. Toll-like receptor 9 contributes to defense against Acinetobacter baumannii infection. Infection and immunity. 2015 Aug 3.
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Rosario-Cruz Z, Chahal HK, Mike LA, Skaar EP, Boyd JM. Bacillithiol has a role in Fe-S cluster biogenesis in Staphylococcus aureus. Molecular microbiology. 2015 Jul 2.
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Cho H, Jeong DW, Liu Q, Yeo WS, Vogl T, Skaar EP, Chazin WJ, Bae T. Calprotectin Increases the Activity of the SaeRS Two Component System and Murine Mortality during Staphylococcus aureus Infections. PLoS pathogens. 2015 Jul;11(11). e1005026.
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Farrand AJ, Haley KP, Lareau NM, Heilbronner S, McLean JA, Foster T, Skaar EP. An Iron-regulated Autolysin Remodels the Cell Wall to Facilitate Heme Acquisition in Staphylococcus lugdunensis. Infection and immunity. 2015 Jun 29.
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Zackular JP, Chazin WJ, Skaar EP. Nutritional Immunity: S100 Proteins at the Host-Pathogen Interface. The Journal of biological chemistry. 2015 Jun 8.
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Skaar EP, Raffatellu M. Metals in infectious diseases and nutritional immunity. Metallomics : integrated biometal science. 2015 May 28.
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Haley KP, Delgado AG, Piazuelo MB, Mortensen BL, Correa P, Damo SM, Chazin WJ, Skaar EP, Gaddy JA. The human antimicrobial protein calgranulin C (S100A12) participates in control of Helicobacter pylori growth and regulation of virulence. Infection and immunity. 2015 May 11.
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Spraggins JM, Rizzo DG, Moore JL, Rose KL, Hammer ND, Skaar EP, Caprioli RM. MALDI FTICR IMS of Intact Proteins: Using Mass Accuracy to Link Protein Images with Proteomics Data. Journal of the American Society for Mass Spectrometry. 2015 Apr 23.
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Messad N, Prasjnar TK, Lina G, O'Callaghan D, Foster SJ, Renshaw SA, Skaar EP, Bes M, Dunyach-Remy C, Vandenesch F, Sotto A, Lavigne JP. Existence of a colonizing Staphylococcus aureus strain isolated in diabetic foot ulcers. Diabetes. 2015 Apr 21.
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Juttukonda LJ, Skaar EP. Manganese Homeostasis and Utilization in Pathogenic Bacteria. Molecular microbiology. 2015 Apr 21.
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Farrand AJ, Friedman DB, Reniere ML, Ingmer H, Frees D, Skaar EP. Proteomic analyses of iron-responsive, Clp-dependent changes in Staphylococcus aureus. Pathogens and disease. 2015 Apr;73(73).
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D'Orazio M, Mastropasqua MC, Cerasi M, Pacello F, Consalvo A, Chirullo B, Mortensen B, Skaar EP, Ciavardelli D, Pasquali P, Battistoni A. The capability of Pseudomonas aeruginosa to recruit zinc under conditions of limited metal availability is affected by inactivation of the ZnuABC transporter. Metallomics : integrated biometal science. 2015 Mar 9.
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Floyd KA, Moore JL, Eberly AR, Good JA, Shaffer CL, Zaver H, Almqvist F, Skaar EP, Caprioli RM, Hadjifrangiskou M. Adhesive Fiber Stratification in Uropathogenic Escherichia coli Biofilms Unveils Oxygen-Mediated Control of Type 1 Pili. PLoS pathogens. 2015 Mar;11(11). e1004697.
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Gaddy JA, Radin JN, Cullen TW, Chazin WJ, Skaar EP, Trent MS, Algood HM. Helicobacter pylori Resists the Antimicrobial Activity of Calprotectin via Lipid A Modification and Associated Biofilm Formation. MBio. 6(6).
2014
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Mashruwala AA, Pang YY, Rosario-Cruz Z, Chahal HK, Benson MA, Anzaldi-Mike LL, Skaar EP, Torres VJ, Nauseef WM, Boyd JM. Nfu facilitates the maturation of iron-sulfur proteins and participates in virulence in Staphylococcus aureus. Molecular microbiology. 2014 Nov 12.
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Luebke JL, Shen J, Bruce KE, Kehl-Fie TE, Peng H, Skaar EP, Giedroc DP. The CsoR-like sulfurtransferase repressor (CstR) is a persulfide sensor in Staphylococcus aureus. Molecular microbiology. 2014 Oct 16.
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Hammer ND, Cassat JE, Noto MJ, Lojek LJ, Chadha AD, Schmitz JE, Creech CB, Skaar EP. Inter- and Intraspecies Metabolite Exchange Promotes Virulence of Antibiotic-Resistant Staphylococcus aureus. Cell host & microbe. 2014 Oct 8;16(16). 531-537.
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Gaddy JA, Radin JN, Loh JT, Piazuelo MB, Kehl-Fie TE, Delgado AG, Ilca FT, Peek RM, Cover TL, Chazin WJ, Skaar EP, Scott Algood HM. The Host Protein Calprotectin Modulates the Helicobacter pylori cag Type IV Secretion System via Zinc Sequestration. PLoS pathogens. 2014 Oct;10(10). e1004450.
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Becker KW, Skaar EP. Metal limitation and toxicity at the interface between host and pathogen. FEMS microbiology reviews. 2014 Sep 11.
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Achouiti A, Vogl T, Endeman H, Mortensen BL, Laterre PF, Wittebole X, Van Zoelen MA, Zhang Y, Hoogerwerf JJ, Florquin S, Schultz MJ, Grutters JC, Biesma DH, Roth J, Skaar EP, Van 't Veer C, De Vos AF, Van der Poll T. Myeloid-related protein-8/14 facilitates bacterial growth during pneumococcal pneumonia. Thorax. 2014 Sep 1.
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Moore JL, Caprioli RM, Skaar EP. Advanced mass spectrometry technologies for the study of microbial pathogenesis. Current opinion in microbiology. 2014 Jul 2;19C(19C). 45-51.
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Mortensen BL, Rathi S, Chazin WJ, Skaar EP. Acinetobacter baumannii response to host-mediated zinc limitation requires the transcriptional regulator Zur. Journal of bacteriology. 2014 May 9.
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Mike LA, Choby JE, Brinkman PR, Olive LQ, Dutter BF, Ivan SJ, Gibbs CM, Sulikowski GA, Stauff DL, Skaar EP. Two-Component System Cross-Regulation Integrates Bacillus anthracis Response to Heme and Cell Envelope Stress. PLoS pathogens. 2014 Mar;10(10). e1004044.
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Thompson MK, Keithly ME, Goodman MC, Hammer ND, Cook PD, Jagessar KL, Harp J, Skaar EP, Armstrong RN. Structure and Function of the Genomically Encoded Fosfomycin Resistance Enzyme, FosB, from Staphylococcus aureus. Biochemistry. 2014 Feb 4;53(53). 755-65.
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Lin L, Pantapalangkoor P, Tan B, Bruhn K, Ho T, Nielsen T, Skaar EP, Zhang Y, Bai R, Wang A, Doherty TM, Spellberg B. Transferrin iron starvation therapy for lethal bacterial and fungal infections. The Journal of infectious diseases. 2014 Jan 19.
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Wakeman CA, Stauff DL, Zhang Y, Skaar EP. Differential activation of Staphylococcus aureus heme detoxification machinery by heme analogues. Journal of bacteriology. 2014 Jan 17.
2013
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Pishchany G, Sheldon JR, Dickson CF, Alam MT, Read TD, Gell DA, Heinrichs DE, Skaar EP. IsdB-dependent hemoglobin binding is required for acquisition of heme by Staphylococcus aureus. The Journal of infectious diseases. 2013 Dec 13.
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Cassat JE, Skaar EP. Recent advances in experimental models of osteomyelitis. Expert review of anti-infective therapy. 2013 Dec;11(11). 1263-5.
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Hood MI, Uzhachenko R, Boyd K, Skaar EP, Ivanova A. Loss of mitochondrial protein FUS1 augments host resistance to Acinetobacter baumannii infection. Infection and immunity. 2013 Sep 16.
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Mike LA, Dutter BF, Stauff DL, Moore JL, Vitko NP, Aranmolate O, Kehl-Fie TE, Sullivan S, Reid PR, DuBois JL, Richardson AR, Caprioli RM, Sulikowski GA, Skaar EP. Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America. 2013 May 14;110(110). 8206-11.
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Mortensen BL, Skaar EP. The contribution of nutrient metal acquisition and metabolism to Acinetobacter baumannii survival within the host. Frontiers in cellular and infection microbiology. 3(3). 95 p.
2003
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Mazmanian SK, Skaar EP, Gaspar AH, Humayun M, Gornicki P, Jelenska J, Joachmiak A, Missiakas DM, Schneewind O. Passage of heme-iron across the envelope of Staphylococcus aureus. Science (New York, N.Y.). 2003 Feb 7;299(299). 906-9.
2002
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Skaar EP, Tobiason DM, Quick J, Judd RC, Weissbach H, Etienne F, Brot N, Seifert HS. The outer membrane localization of the Neisseria gonorrhoeae MsrA/B is involved in survival against reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America. 2002 Jul 23;99(99). 10108-13.
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Skaar EP, Seifert HS. The misidentification of bacterial genes as human cDNAs: was the human D-1 tumor antigen gene acquired from bacteria? Genomics. 2002 May;79(79). 625-7.
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Skaar EP, Lazio MP, Seifert HS. Roles of the recJ and recN genes in homologous recombination and DNA repair pathways of Neisseria gonorrhoeae. Journal of bacteriology. 2002 Feb;184(184). 919-27.
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Hickman JW, Barber RD, Skaar EP, Donohue TJ. Link between the membrane-bound pyridine nucleotide transhydrogenase and glutathione-dependent processes in Rhodobacter sphaeroides. Journal of bacteriology. 2002 Jan;184(184). 400-9.