Pathogenesis of myelodysplastic syndrome and acute myeloid leukemia
Pathogenesis and classification of Acute Myeloid Leukemia and Myelodysplastic Syndrome
Half of clinical acute myeloid leukemia (AML) is preceded by or similar to Myelodysplastic Syndrome (MDS)(also known as preleukemia). This set of diseases is refractory to current treatment except stem cell transplantation (SCT). Because of its age distribution (elderly), most patients are ineligible for SCT. The pathogenesis of these diseases is unknown, but some data suggest a relationship to interstrand crosslink (ICL) DNA damage. The repair system for correcting such damage is largely unknown. We are evaluating genes upregulated in response to ICL damage as genes possiblly relevant to the pathogenesis of MDS and AML.