Ph.D. (1981) – University of Amsterdam and The Netherlands Cancer Institute, Amsterdam (Biochemistry)
University of Amsterdam and NIMR, Mill Hill, UK
Postdoctoral Fellowship - University of California, San Francisco
Dr. de Lange earned her Ph.D. in biochemistry from the University of Amsterdam and the Netherlands Cancer Institute in 1985. From 1985 to 1990 she was a postdoctoral fellow in the laboratory of Nobel laureate Harold Varmus at the University of California, San Francisco, where she was one of the first to isolate the telomeres of human chromosomes.
Telomeres are highly specialized DNA-protein structures that cap the ends of linear chromosomes and prevent the activation of the DNA damage response. Impaired functioning of telomeres can lead to genomic instability, and so to cancer, as well as accelerate the aging process
Dr. de Lange is the Leon Hess Professor and the Director of the Anderson Center for Cancer Research at the Rockefeller University. Sir Paul Nurse, Nobel laureate, and Marc Tessier-Lavigne, Ph.D., then President of Rockefeller University, nominated de Lange for the Vanderbilt Prize in Biomedical Science.
Dr. de Lange is the winner of the 2011 Vanderbilt Prize in Biomedical Science and also the recipient of the 2014 Gairdner International Award, the 2013 Breakthrough Prize in Life Sciences, the 2011 Vilcek Prize in Biomedical Science, the 2010 AACR Clowes Memorial Award, the 2008 Massachusetts General Hospital Cancer Center Prize, and the first Paul Marks Prize for Cancer Research, in 2001.
She is an elected member of the Royal Dutch Academy of Sciences, the European Molecular Biology Organization, the American Academy of Arts and Sciences, the Institute of Medicine, and a foreign associate of the National Academy of Sciences.